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How is an anti-CCP antibody test used to diagnose rheumatoid arthritis?

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This test finds immune system chemicals, called antibodies, that target CCP (cyclic citrullinated peptide), which is present in about 60% to 70% of people with rheumatoid arthritis (RA). You could have these antibodies years before you get RA symptoms. This test can also predict cases of RA that could become severe. But it misses 10% to 15% of cases of RA. So you'll need other tests, too.

SOURCES:

Arthritis Foundation: "Guide to Lab Tests."

Medline Plus, Medical Encyclopedia: "Rheumatoid Factor."

MedicineNet.com: "Rheumatoid Factor."

University of Maryland Medical Center: "Rheumatoid Arthritis - Diagnosis."

The Johns Hopkins Arthritis Center: "RA and Normal Blood Tests."

Lupus Foundation of America: "The Antinuclear Antibody Test: What It Means."

University of Washington, Department of Orthopedics and Sports Medicine: "Lab Tests."

Reviewed by David Zelman on May 22, 2019

SOURCES:

Arthritis Foundation: "Guide to Lab Tests."

Medline Plus, Medical Encyclopedia: "Rheumatoid Factor."

MedicineNet.com: "Rheumatoid Factor."

University of Maryland Medical Center: "Rheumatoid Arthritis - Diagnosis."

The Johns Hopkins Arthritis Center: "RA and Normal Blood Tests."

Lupus Foundation of America: "The Antinuclear Antibody Test: What It Means."

University of Washington, Department of Orthopedics and Sports Medicine: "Lab Tests."

Reviewed by David Zelman on May 22, 2019

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Are there drawbacks of an anti-CCP antibody test used to diagnose rheumatoid arthritis?

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