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What are symptoms of high TNF?

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High TNF levels can trigger some unpleasant symptoms:

If you have psoriasis, high TNF levels play a role in the raised, red skin plaques that come with the disease. For people with RA, it's joint swelling and redness.

  • Low blood pressure
  • Fever
  • Muscle aches
  • Loss of appetite
  • Redness and swelling (if you have an infected wound)

From: How Does TNF Cause Inflammation? WebMD Medical Reference

American College of Rheumatology: “TNF Inhibitors.”

Institute for Quality and Efficiency in Health Care: “What Is An Inflammation?”

Arthritis Research UK: “The Science Behind the Success of Anti-TNF Therapy.”

Arundathi Jayatilleke, MD, assistant professor, department of medicine, division of rheumatology, Drexel University College of Medicine, Philadelphia.

The Oncologist : “The Molecular Perspective: Tumor Necrosis Factor.”

UpToDate: “Patient education: Rheumatoid arthritis treatment (Beyond the Basics).”

FDA: “Information on Tumor (TNF) Blockers (marketed as Remicade, Enbrel, Humira, Cimzia, and Simponi).”

JAMA : “Non–TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.”

Arthritis Foundation: “Biologics Overview.”

Reviewed by David Zelman on August 23, 2018

American College of Rheumatology: “TNF Inhibitors.”

Institute for Quality and Efficiency in Health Care: “What Is An Inflammation?”

Arthritis Research UK: “The Science Behind the Success of Anti-TNF Therapy.”

Arundathi Jayatilleke, MD, assistant professor, department of medicine, division of rheumatology, Drexel University College of Medicine, Philadelphia.

The Oncologist : “The Molecular Perspective: Tumor Necrosis Factor.”

UpToDate: “Patient education: Rheumatoid arthritis treatment (Beyond the Basics).”

FDA: “Information on Tumor (TNF) Blockers (marketed as Remicade, Enbrel, Humira, Cimzia, and Simponi).”

JAMA : “Non–TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug: A Randomized Clinical Trial.”

Arthritis Foundation: “Biologics Overview.”

Reviewed by David Zelman on August 23, 2018

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What happens when TNF causes too much inflammation?

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