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What is a tumor necrosis factor inhibitor?

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Tumor necrosis factor (TNF) inhibitors are drugs that help stop inflammation. They're used to treat diseases like rheumatoid arthritis, juvenile arthritis, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, ulcerative colitis, and Crohn's disease. They're also called TNF blockers, biologic therapies, or anti-TNF drugs. There are six available now, all by prescription only:

  • Adalimumab (Humira)
  • Adalimumab-atto (Amjevita), a biosimilar to Humira
  • Certolizumab pegol (Cimzia)
  • Etanercept (Enbrel)
  • Etanercept-szzs (Erelzi), a biosimilar to Enbrel
  • Golimumab (Simponi, Simponi Aria)
  • Infliximab (Remicade)
  • Infliximab-dyyb (Inflectra), a biosimilar to Remicade

From: What Is a TNF Inhibitor? WebMD Medical Reference

SOURCES:

American College of Rheumatology: "Anti-TNF Drugs."

Crohn's and Colitis Foundation of America: "Biologic Therapies."

FDA. "FDA approves Amjevita, a biosimilar to Humira.”

Johns Hopkins Arthritis Center: "Rheumatoid Arthritis Treatment."

Ma, X and Xu, S. . Published online, November 2012. Biomedical Reports

MedlinePlus: "Etanercept Injection."

National Rheumatoid Arthritis Society: "Anti-TNFa Treatment in Rheumatoid Arthritis."

Tanaka, Y. , 2013.                Clinical and Experimental Rheumatology

Reviewed by David Zelman on December 14, 2018

SOURCES:

American College of Rheumatology: "Anti-TNF Drugs."

Crohn's and Colitis Foundation of America: "Biologic Therapies."

FDA. "FDA approves Amjevita, a biosimilar to Humira.”

Johns Hopkins Arthritis Center: "Rheumatoid Arthritis Treatment."

Ma, X and Xu, S. . Published online, November 2012. Biomedical Reports

MedlinePlus: "Etanercept Injection."

National Rheumatoid Arthritis Society: "Anti-TNFa Treatment in Rheumatoid Arthritis."

Tanaka, Y. , 2013.                Clinical and Experimental Rheumatology

Reviewed by David Zelman on December 14, 2018

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What tumor necrosis factor inhibitors are available for use?

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