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What are the side effects of leflunomide (Arava)?

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Leflunomide (Arava) works about as well as methotrexate and can work even better in combination with it. The side effects are similar to methotrexate. Sometimes, Arava causes diarrhea and can't be used. Since Arava is known to cause harm to a fetus, women must take special precautions to prevent pregnancy.

SOURCES:

American College of Rheumatology Ad Hoc Committee on Clinical Guidelines, Guidelines for the management of rheumatoid arthritis: 2002 update, , 2002. Arthritis and Rheumatism

Harris, E., , W.B. Saunders, 2005.  Kelley's Textbook of Rheumatology, 7th edition

Klippel, John H., , 12th edition, Arthritis Foundation, 2001.  Primer on the Rheumatic Diseases

Maetzel A., , December 1998.  Journal of Rheumatology

RxList.com: Patient Drug Information. 

Reviewed by David Zelman on October 13, 2019

SOURCES:

American College of Rheumatology Ad Hoc Committee on Clinical Guidelines, Guidelines for the management of rheumatoid arthritis: 2002 update, , 2002. Arthritis and Rheumatism

Harris, E., , W.B. Saunders, 2005.  Kelley's Textbook of Rheumatology, 7th edition

Klippel, John H., , 12th edition, Arthritis Foundation, 2001.  Primer on the Rheumatic Diseases

Maetzel A., , December 1998.  Journal of Rheumatology

RxList.com: Patient Drug Information. 

Reviewed by David Zelman on October 13, 2019

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What are the side effects of methotrexate?

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