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What drugs are used to treat nausea and vomiting but can cause neuroleptic malignant syndrome (NMS)?

ANSWER

Some drugs used to treat nausea and vomiting can also cause NMS, because they block dopamine. These include:

People who take drugs for Parkinson's disease, like levodopa, can get NMS if they stop taking their medicine too quickly.

  • Domperidone (Motilium)
  • Droperidol (Inapsine)
  • Metoclopramide (Reglan)
  • Prochlorperazine (Compazine)
  • Promethazine (Phenergan)

SOURCES:

Kateon, H. , published online September 2013. Mental Health Clinician

Merck Manual Professional Version: "Neuroleptic Malignant Syndrome."

National Institute of Neurological Disorders and Stroke: "NINDS Neuroleptic Malignant Syndrome Information Page."

National Organization for Rare Disorders: "Neuroleptic Malignant Syndrome."

OrphaNet: "Neuroleptic Malignant Syndrome."

Reviewed by Jennifer Casarella on December 4, 2019

SOURCES:

Kateon, H. , published online September 2013. Mental Health Clinician

Merck Manual Professional Version: "Neuroleptic Malignant Syndrome."

National Institute of Neurological Disorders and Stroke: "NINDS Neuroleptic Malignant Syndrome Information Page."

National Organization for Rare Disorders: "Neuroleptic Malignant Syndrome."

OrphaNet: "Neuroleptic Malignant Syndrome."

Reviewed by Jennifer Casarella on December 4, 2019

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What are symptoms of neuroleptic malignant syndrome (NMS)?

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