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What older antipsychotic drugs can cause neuroleptic malignant syndrome (NMS)?

ANSWER

NMS is very rare. Only about 1 to 2 out of every 10,000 people who take antipsychotic drugs get it.

All antipsychotic drugs can cause NMS. The older antipsychotic drugs include:

  • Chlorpromazine (Thorazine)
  • Fluphenazine (Prolixin)
  • Haloperidol (Haldol)
  • Loxapine (Loxitane)
  • Perphenazine (Etrafon)
  • Thioridazine (Mellaril)

SOURCES:

Kateon, H. , published online September 2013. Mental Health Clinician

Merck Manual Professional Version: "Neuroleptic Malignant Syndrome."

National Institute of Neurological Disorders and Stroke: "NINDS Neuroleptic Malignant Syndrome Information Page."

National Organization for Rare Disorders: "Neuroleptic Malignant Syndrome."

OrphaNet: "Neuroleptic Malignant Syndrome."

Reviewed by Jennifer Casarella on December 4, 2019

SOURCES:

Kateon, H. , published online September 2013. Mental Health Clinician

Merck Manual Professional Version: "Neuroleptic Malignant Syndrome."

National Institute of Neurological Disorders and Stroke: "NINDS Neuroleptic Malignant Syndrome Information Page."

National Organization for Rare Disorders: "Neuroleptic Malignant Syndrome."

OrphaNet: "Neuroleptic Malignant Syndrome."

Reviewed by Jennifer Casarella on December 4, 2019

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What newer antipsychotic drugs can cause neuroleptic malignant syndrome (NMS)?

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