Medically Reviewed by Stephanie S. Gardner, MD on April 26, 2022

photo of amiodarone on senior man's face

Amiodarone. Hyperpigmentation is a rare but possible side effect of the medication amiodarone which is used to treat heart arrhythmia. The patient can develop a slate-gray pigmentation of the skin in areas exposed to the sun, such as the face. . In most cases, these skin returns to normal eventually after the medication is stopped.

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