Erythema infectiosum (fifth disease). Erythema infectiosum is a mild childhood disease that is caused by human parvovirus B19. This condition develops after a mean incubation period of 14 days. There are few if any prodromal symptoms, but fevers usually accompany the illness. The rash evolves in three clinical stages. The first stage is characterized by the abrupt appearance of a bright-red malar blush. The appearance is so startling that it has been given the suggestive description of “slapped cheeks”. During the second stage, the facial rash begins to fade, and a maculopapular, urticarial, or morbilliform exanthem develops on the extremities and trunk. Pruritus may be present.
Color Atlas of Pediatric Dermatology
Samuel Weinberg, Neil S. Prose, Leonard Kristal
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