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Body-wide Issues

Crohn's disease is an inflammatory condition. That inflammation primarily affects the intestines. But fever might be a sign of Crohn's, particularly when it happens in conjunction with other symptoms. Fever suggests systemic inflammation, which could be stemming from inflammation in the bowel.

Unexplained weight loss can also be a symptom of Crohn's because body-wide inflammation has the potential to speed up your metabolism. Meanwhile, people with Crohn's often lose weight if they aren’t absorbing nutrients like they should. That's most likely to happen when the bowel gets ulcerated or inflamed or because you have chronic diarrhea.

Non-GI Complications

When someone has severe Crohn's disease or is experiencing a flare, it isn’t only their digestive system that's in trouble. Some people with Crohn's develop eye problems such as episcleritis, scleritis, and uveitis, which are different types of eye inflammation. They can cause redness and vision trouble.

Inflammation associated with Crohn's can also lead to skin symptoms, like tiny red bumps (erythema nodosum) or sores (pyoderma gangrenosum) that appear on the arms or legs.

Another possible complication is a disease of the bile ducts called primary sclerosing cholangitis. It's more common in people with ulcerative colitis (the other type of IBD), but it does occur in some people with Crohn's.