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How do biologics improve psoriasis?

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In general, biologics improve your psoriasis because they:

The patches and plaques of psoriasis develop after an interaction between skin cells and white blood cells. Biologics interfere with TNF-alpha or T cells, or they target interleukins. This short-circuits the unhealthy link between the two cell types. Your inflammation (redness and itch) will ease and you'll have less growth of thick, scaly skin.

  • Curb T cells (a form of white blood cell)
  • Block a substance called tumor necrosis factor-alpha (TNF-alpha), one of the main messenger chemicals in the immune system
  • Block a family of the immune system's chemical messengers called interleukins
  • Bind to proteins that cause inflammation

From: The Latest in Psoriasis Treatment WebMD Medical Reference

SOURCES:

Callen, J.P.,   2003; vol 49: pp 351-356. Journal of the American Academy of Dermatology,

FDA: "FDA approves new psoriasis drug Taltz."

News release, FDA: "FDA approves Amjevita, a biosimilar to Humira." 

Lebwohl, M.,   2003; vol 49: pp S118-S124. Journal of the American Academy of Dermatology,

Lowes, M.A.,  , 2007; vol 445: pp 866-873. Nature

Nickoloff, B.J.,   2004; vol 113: pp 1664-1675. Journal of Clinical Investigation,

Saini, R.,   2005; vol 11: pp 273-280. Current Pharmaceutical Design,

Reviewed by Debra Jaliman on June 25, 2019

SOURCES:

Callen, J.P.,   2003; vol 49: pp 351-356. Journal of the American Academy of Dermatology,

FDA: "FDA approves new psoriasis drug Taltz."

News release, FDA: "FDA approves Amjevita, a biosimilar to Humira." 

Lebwohl, M.,   2003; vol 49: pp S118-S124. Journal of the American Academy of Dermatology,

Lowes, M.A.,  , 2007; vol 445: pp 866-873. Nature

Nickoloff, B.J.,   2004; vol 113: pp 1664-1675. Journal of Clinical Investigation,

Saini, R.,   2005; vol 11: pp 273-280. Current Pharmaceutical Design,

Reviewed by Debra Jaliman on June 25, 2019

NEXT QUESTION:

What are some biologic medicines that treat moderate to severe psoriasis?

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THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

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