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How does Methotrexate treat psoriasis?

ANSWER

Methotrexate eases symptoms by curbing your immune system and slowing the rapid growth of skin cells.

You take it once a week either by mouth or in a shot. You should see results after 4 to 6 weeks.

This drug can have serious side effects. At first, you might have nausea or fatigue. Over time, it can damage your liver and blood cells.

Tell your doctor about any other health issues you have. Methotrexate isn't safe for people with anemia or liver disease. You should also limit how much alcohol you drink. Even one glass a day while you're on it can cause liver problems. You'll need regular blood tests so your doctor can check on your blood cells and liver.

Men and women both should stop taking it when planning a pregnancy.

SOURCES:

Abel, E. "Psoriasis," , BC Decker, 2005. ACP Medicine

American Academy of Dermatology.

American College of Rheumatology: "Psoriatic Arthritis."

FDA. "FDA approves new psoriasis drug Taltz," “FDA approves Inflectra, a biosimilar to Remicade,” “FDA approves Amjevita, a biosimilar to Humira.”

Jeffrey M. Weinberg, MD, Mount Sinai St. Luke's, New York; associate clinical professor of dermatology, Columbia University College of Physicians and Surgeons; consultant to Amgen and Genentech.

Medscape: "FDA OKs Biologic Guselkumab (Tremfya) for Plaque Psoriasis."

National Institute of Arthritis and Musculoskeletal and Skin Diseases.

National Psoriasis Foundation.

Strober, Bruce E., MD, PhD, associate professor, vice chairman, director of clinical trials, department of dermatology, University of Connecticut; consultant to NexGenix Pharmaceuticals Holdings, Amgen, Biogen, Genentech, Fujisawa, and 3M.

Reviewed by Stephanie S. Gardner on July 17, 2019

SOURCES:

Abel, E. "Psoriasis," , BC Decker, 2005. ACP Medicine

American Academy of Dermatology.

American College of Rheumatology: "Psoriatic Arthritis."

FDA. "FDA approves new psoriasis drug Taltz," “FDA approves Inflectra, a biosimilar to Remicade,” “FDA approves Amjevita, a biosimilar to Humira.”

Jeffrey M. Weinberg, MD, Mount Sinai St. Luke's, New York; associate clinical professor of dermatology, Columbia University College of Physicians and Surgeons; consultant to Amgen and Genentech.

Medscape: "FDA OKs Biologic Guselkumab (Tremfya) for Plaque Psoriasis."

National Institute of Arthritis and Musculoskeletal and Skin Diseases.

National Psoriasis Foundation.

Strober, Bruce E., MD, PhD, associate professor, vice chairman, director of clinical trials, department of dermatology, University of Connecticut; consultant to NexGenix Pharmaceuticals Holdings, Amgen, Biogen, Genentech, Fujisawa, and 3M.

Reviewed by Stephanie S. Gardner on July 17, 2019

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