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How does psoriasis affect brain chemicals?

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With psoriasis, your immune cells release substances called cytokines. These make skin cells grow out of control and form scaly plaques. They also change levels of chemicals in your brain that affect your mood. A cytokine called TNF-alpha may affect brain chemicals like serotonin in a way that could lead to depression.

SOURCES:

American Council on Science and Health: "Psoriasis Causes Depression, And Here's Why."

Archives of Dermatology : "The risk of depression, anxiety and suicidality in patients with psoriasis: A population-based cohort study."

Arthritis Foundation: "How Common is Psoriatic Arthritis in People with Psoriasis?"

British Journal of Dermatology : "A cognitive-behavioural symptom management programme as an adjunct in psoriasis therapy."

Cytokine : "Cytokines in psoriasis."

Expert Opinion on Pharmacotherapy: "Impact and management of depression in psoriasis patients."

JAMA Dermatology : "Psoriasis and the risk of depression in the US Population: National Health and Nutrition Examination Survey 2009-2012."

Journal of the European Academy of Dermatology and Venereology : "Effect of biologics on depressive symptoms in patients with psoriasis: a systematic review."

Mayo Clinic: "Depression (major depressive disorder): Symptoms."

National Psoriasis Foundation: "Mind and Body Therapies," "The link between psoriatic disease and mental illness."

Neuroscience : "Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications."

News release, American Academy of Dermatology, August 2015.

The Journal of Investigative Dermatology : "The psychological burden of skin diseases: A cross-sectional multicenter study among dermatological out-patients in 13 European countries."

Reviewed by Debra Jaliman on May 3, 2019

SOURCES:

American Council on Science and Health: "Psoriasis Causes Depression, And Here's Why."

Archives of Dermatology : "The risk of depression, anxiety and suicidality in patients with psoriasis: A population-based cohort study."

Arthritis Foundation: "How Common is Psoriatic Arthritis in People with Psoriasis?"

British Journal of Dermatology : "A cognitive-behavioural symptom management programme as an adjunct in psoriasis therapy."

Cytokine : "Cytokines in psoriasis."

Expert Opinion on Pharmacotherapy: "Impact and management of depression in psoriasis patients."

JAMA Dermatology : "Psoriasis and the risk of depression in the US Population: National Health and Nutrition Examination Survey 2009-2012."

Journal of the European Academy of Dermatology and Venereology : "Effect of biologics on depressive symptoms in patients with psoriasis: a systematic review."

Mayo Clinic: "Depression (major depressive disorder): Symptoms."

National Psoriasis Foundation: "Mind and Body Therapies," "The link between psoriatic disease and mental illness."

Neuroscience : "Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications."

News release, American Academy of Dermatology, August 2015.

The Journal of Investigative Dermatology : "The psychological burden of skin diseases: A cross-sectional multicenter study among dermatological out-patients in 13 European countries."

Reviewed by Debra Jaliman on May 3, 2019

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What are some signs someone with psoriasis is depressed?

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