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What biologic drugs are used to treat moderate or severe psoriasis?

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Biologic drugs used to treat psoriasis include:

1. Ixekizumab (Taltz) and secukinumab (Cosentyx). These are antibodies that bind to interleukin-17A, a protein that is involved in inflammation.

2. Tumor necrosis factor-alpha blockers, including adalimumab (Humira), adalimumab-atto (Amjevita), etanercept (Enbrel), etanercept-szzs (Erelzi), and infliximab (Remicade). These drugs block a chemical messenger of the immune system called TNF-alpha. People with psoriasis have too much of this substance, which causes inflammation.

3. Ustekinumab (Stelara). This drug blocks cytokines in the body called interleukin-12 and interleukin-23, which experts believe promote the increased growth rate of skin cells and inflammation from psoriasis.

SOURCES:

American Academy of Dermatology. Bhosle, M. , June 2006. FDA. "FDA approves new psoriasis drug Taltz." “FDA approves Amjevita, a biosimilar to Humira. National Psoriasis Foundation.


Health and Quality of Life Outcomes

Reviewed by Stephanie S. Gardner on October 30, 2017

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SOURCES:

American Academy of Dermatology. Bhosle, M. , June 2006. FDA. "FDA approves new psoriasis drug Taltz." “FDA approves Amjevita, a biosimilar to Humira. National Psoriasis Foundation.


Health and Quality of Life Outcomes

Reviewed by Stephanie S. Gardner on October 30, 2017

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