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What are IgA mediated bullous dermatoses?

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IgA mediated bullous dermatoses are disorders in which the immune system makes a lot of immunoglobulin A (IgA), an antibody that fights bacteria, toxins, and viruses. There are two types:

  • Dermatitis herpetiformis affects people with celiac disease. It causes clusters of itchy blisters on the elbows, knees, scalp, and buttocks.
  • Linear IgA disease causes new blisters to form a ring around old ones on the skin. This is sometimes called a “cluster of jewels.” It affects mucous membranes, too.

SOURCES:

Cleveland Clinic: "Blistering Diseases."

DermNet New Zealand: "Intravenous immunoglobulin," "Mucous membrane pemphigoid."

National Health Service: "Bullous pemphigoid."

National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Pemphigus."

National Organization for Rare Disorders: "Autoimmune Blistering Diseases."

Reviewed by Stephanie S. Gardner on November 12, 2018

SOURCES:

Cleveland Clinic: "Blistering Diseases."

DermNet New Zealand: "Intravenous immunoglobulin," "Mucous membrane pemphigoid."

National Health Service: "Bullous pemphigoid."

National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Pemphigus."

National Organization for Rare Disorders: "Autoimmune Blistering Diseases."

Reviewed by Stephanie S. Gardner on November 12, 2018

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I have an autoimmune blistering disorder. What problems can blisters cause?

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