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What are the severe side effects of human papillomavirus (HPV) vaccine?

ANSWER

Severe side effects, or adverse events, are uncommonly reported and have included:

Government, academic, and other public health investigators could not identify the HPV vaccine as the cause of any severe adverse event. There were 117 deaths as of September 2015, none of which could be directly tied to the HPV vaccine. Public health investigators concluded that the HPV vaccine was unlikely to cause these events. Such events occur at a certain rate in any group of tens of millions of people. The vaccination before each adverse event seemed to be a simple coincidence.

  • Blood clots
  • Seizures
  • Guillain-Barré syndrome
  • Chronic inflammatory demyelinating polyneuropathy
  • Mylgic encephalomyelitis/chronic fatigue syndrome
  • Death

From: HPV Vaccine for Adults WebMD Medical Reference

SOURCES:

CDC web site: ''Cervical Cancer Statistics,'' ''HPV Vaccine -- Questions & Answers;'' ''Genital HPV Infection --Fact Sheet;'' ''ACIP Recommendations on HPV;'' ''Human Papillomavirus (HPV);''  "HPV and Oropharyngeal Cancer - Fact Sheet;" and "Morbidity and Mortality Weekly Report," June 25, 2014.

National Cancer Institute web site: ''Human Papillomavirus (HPV) Vaccines.''

Merck web site: Gardasil package insert prescribing information.

GlaxoSmithKline web site: Cervarix package insert prescribing information.

Koutsky, L. , 1997. The American Journal of Medicine

Syrjanen, K. 1990. Sexually Transmitted Diseases,

FDA: "FDA approves Gardasil 9 for prevention of certain cancers caused by five additional types of HPV."

Reviewed by Jennifer Robinson on March 27, 2017

WAS THIS ANSWER HELPFUL

SOURCES:

CDC web site: ''Cervical Cancer Statistics,'' ''HPV Vaccine -- Questions & Answers;'' ''Genital HPV Infection --Fact Sheet;'' ''ACIP Recommendations on HPV;'' ''Human Papillomavirus (HPV);''  "HPV and Oropharyngeal Cancer - Fact Sheet;" and "Morbidity and Mortality Weekly Report," June 25, 2014.

National Cancer Institute web site: ''Human Papillomavirus (HPV) Vaccines.''

Merck web site: Gardasil package insert prescribing information.

GlaxoSmithKline web site: Cervarix package insert prescribing information.

Koutsky, L. , 1997. The American Journal of Medicine

Syrjanen, K. 1990. Sexually Transmitted Diseases,

FDA: "FDA approves Gardasil 9 for prevention of certain cancers caused by five additional types of HPV."

Reviewed by Jennifer Robinson on March 27, 2017

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