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Can premenstrual syndrome be treated by L-tryptophan?

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Some women take L-tryptophan supplements to try to ease mood swings caused by premenstrual syndrome (PMS), also called premenstrual dysphoric disorder (PMDD). The theory is that these conditions may be linked to a problem with serotonin, and that L-tryptophan could help that. But there is little evidence to show this really works.

From: L-tryptophan WebMD Medical Reference

SOURCES:

News release, National Institute of Mental Health.

National Center for Complementary and Alternative Medicine web site: "Sleep Disorders and CAM."

Allan, J.A. , November 2011. Arthritis and Rheumatism

Fernstrom J.D. , December 2012. The Journal of Nutrition

Castell, L.M. , 1999. Advances in Experimental Medicine and Biology

Shannon, M.W., Borron, S.W., Burns, M.J., editors, , 4th edition, Saunders Elsevier, 2007. Shannon: Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose

Gold Standard Database: "L-tryptophan Drug Monograph."

Kemper, K.J. , December 2007. Pediatric Clinics of North America

Vigod, S. , June 2010. Psychiatric Clinics of North America

Alternative Medicine Review , 2006.

Lieberman, H.R., Journal of Nutrition, December 2016. Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression and Sleep Outcomes.

Yurcheshen M, Seehuus M, Pigeon W. 2015 Updates on Nutraceutical Sleep Therapeutics and Investigational Research.Evidence-based Complementary and Alternative Medicine,

Richard, D., Dawes, M., Mathias, C., Acheson, A., Hill-Kapturczak, N., Dougherty, D: - , International Journal of Tryptophan Research 2013 LTryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

Sarris J, A . Am J Psychiatry. June 2016 djunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

Reviewed by Carmen Patrick Mohan on May 12, 2017

SOURCES:

News release, National Institute of Mental Health.

National Center for Complementary and Alternative Medicine web site: "Sleep Disorders and CAM."

Allan, J.A. , November 2011. Arthritis and Rheumatism

Fernstrom J.D. , December 2012. The Journal of Nutrition

Castell, L.M. , 1999. Advances in Experimental Medicine and Biology

Shannon, M.W., Borron, S.W., Burns, M.J., editors, , 4th edition, Saunders Elsevier, 2007. Shannon: Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose

Gold Standard Database: "L-tryptophan Drug Monograph."

Kemper, K.J. , December 2007. Pediatric Clinics of North America

Vigod, S. , June 2010. Psychiatric Clinics of North America

Alternative Medicine Review , 2006.

Lieberman, H.R., Journal of Nutrition, December 2016. Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression and Sleep Outcomes.

Yurcheshen M, Seehuus M, Pigeon W. 2015 Updates on Nutraceutical Sleep Therapeutics and Investigational Research.Evidence-based Complementary and Alternative Medicine,

Richard, D., Dawes, M., Mathias, C., Acheson, A., Hill-Kapturczak, N., Dougherty, D: - , International Journal of Tryptophan Research 2013 LTryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

Sarris J, A . Am J Psychiatry. June 2016 djunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

Reviewed by Carmen Patrick Mohan on May 12, 2017

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What conditions can be treated with L-tryptophan supplements?

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