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What are the benefits of taking L-citrulline?

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The animal research suggests L-citrulline may help treat intestinal problems, including:

  • Short bowel syndrome
  • Celiac disease
  • Radiation-caused small bowel damage

Certain genetic disorders and health conditions such as liver disease may be helped by L-citrulline supplements. Early human studies done also hint that L-citrulline may be helpful for Parkinson's disease and certain dementias. Some people also take L-citrulline to build muscles and improve athletic performance, but research shows it does not help well-trained athletes perform or exercise better.

SOURCES:

News releases, National Standard Database: "L-Citrulline May Lower Blood Pressure," "Watermelon and Viagra."

Venes, D., editor, Taber's Cyclopedic Medical Dictionary, 19th edition. F.A. Davis Company, 2001.

Cormio, L. Urology, January 2011.

Smith, H. The Journal of Thoracic and Cardiovascular Surgery, July 2006.

Sureda, A. Medicine and Sport Science, 2013.

National Medicines Comprehensive Medicines web site. "L-Citrulline Monograph."

DiPetrio, N. Atherosclerosis, Nov. 8, 2012.

Osowska, S. American Journal of Physiology, Endocrinology, and Metabolism, 2006.

Curis, E. Amino Acids, 2005.

Carpenter, T.O.  New England Journal of Medicine, 1985.

Jesse, S. CNS Neuroscience and Therapeutics, June 2009.

Tremblay, G.C. New England Journal of Medicine, 1975.

Mandel H. Journal of Inherited Metabolic Disease, 2005.

Diego M. C., Zhao-Jun Liu, Omaida C. V. Oxygen: Implications of Wound Healing, 2012

Reviewed by Melinda Ratini on September 24, 2019

SOURCES:

News releases, National Standard Database: "L-Citrulline May Lower Blood Pressure," "Watermelon and Viagra."

Venes, D., editor, Taber's Cyclopedic Medical Dictionary, 19th edition. F.A. Davis Company, 2001.

Cormio, L. Urology, January 2011.

Smith, H. The Journal of Thoracic and Cardiovascular Surgery, July 2006.

Sureda, A. Medicine and Sport Science, 2013.

National Medicines Comprehensive Medicines web site. "L-Citrulline Monograph."

DiPetrio, N. Atherosclerosis, Nov. 8, 2012.

Osowska, S. American Journal of Physiology, Endocrinology, and Metabolism, 2006.

Curis, E. Amino Acids, 2005.

Carpenter, T.O.  New England Journal of Medicine, 1985.

Jesse, S. CNS Neuroscience and Therapeutics, June 2009.

Tremblay, G.C. New England Journal of Medicine, 1975.

Mandel H. Journal of Inherited Metabolic Disease, 2005.

Diego M. C., Zhao-Jun Liu, Omaida C. V. Oxygen: Implications of Wound Healing, 2012

Reviewed by Melinda Ratini on September 24, 2019

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