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What are the risks of taking 5-HTP (5-hydroxytryptophan) supplements?

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5-HTP supplements may cause cramping, heartburn, gas, diarrhea, irregular heartbeats, rash, and loss of appetite.

Contaminated 5-HTP supplements have led to dangerous side effects, like seizures and a life-threatening neurological condition.

There's no standard dose for 5-HTP. For depression, typical dosages range from 150 to 300 milligrams a day, or sometimes even higher. Ask your doctor for advice.

From: 5-HTP (5-Hydroxytryptophan) WebMD Medical Reference

SOURCES:

Fundukian, L. ed., , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Natural Medicines Comprehensive Database web site: "5-HTP."

Rakel D. , 3rd edition, Saunders, 2012. Integrative Medicine

Turner, E. , 2006. Pharmacology & Therapeutics

Das, Y. , 2004. Toxicology Letters

Reviewed by Melinda Ratini on October 06, 2019

SOURCES:

Fundukian, L. ed., , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Natural Medicines Comprehensive Database web site: "5-HTP."

Rakel D. , 3rd edition, Saunders, 2012. Integrative Medicine

Turner, E. , 2006. Pharmacology & Therapeutics

Das, Y. , 2004. Toxicology Letters

Reviewed by Melinda Ratini on October 06, 2019

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Who should not use 5-HTP (5-hydroxytryptophan) supplements?

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THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

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