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    Other Names:

    5,7-Chrysin, 5,7-Dihydroxyflavone, Chrysine, Flavone X, Flavonoid, Flavonoïde, Galangin Flavanone, Galangine Flavanone.

    CHRYSIN Overview
    CHRYSIN Uses
    CHRYSIN Side Effects
    CHRYSIN Interactions
    CHRYSIN Dosing
    CHRYSIN Overview Information

    Chrysin belongs to a class of chemicals called flavonoids. It occurs naturally in plants such as the passionflower, silver linden, and some geranium species; and in honey and bee propolis (glue).

    Chrysin is used for bodybuilding; for treating anxiety, inflammation, gout, HIV/AIDS, erectile dysfunction (ED), and baldness; and for preventing cancer.

    How does it work?

    Athletes are interested in chrysin for bodybuilding because laboratory research suggested that chrysin might increase the male hormone called testosterone and improve bodybuilding results. But research in humans hasn't found any effect on testosterone levels. The amount of chrysin that is absorbed from the intestine may be very small, which would make treatment effects unlikely.

    CHRYSIN Uses & Effectiveness What is this?

    Possibly Ineffective for:

    • Athletic performance. Taking chrysin by mouth in combination with steroids and other supplements for 8 weeks does not seem to be effective for enhancing resistance training in athletes.

    Insufficient Evidence for:

    More evidence is needed to rate the effectiveness of chrysin for these uses.

    CHRYSIN Side Effects & Safety

    Chrysin is POSSIBLY SAFE for most adults when taken by mouth for up to 8 weeks. No adverse effects have been reported.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking chrysin if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

    Bleeding disorder: Chrysin might increase bleeding. There is some concern that it might increase the risk of bruising and bleeding in people with bleeding disorders.

    Surgery: Chrysin might slow blood clotting. There is concern that it might increase the risk of extra bleeding during and after surgery. Stop taking chrysin at least 2 weeks before a scheduled surgery.

    CHRYSIN Interactions What is this?

    Moderate Interaction Be cautious with this combination

    • Medications for estrogen sensitive cancers (Aromatase inhibitors) interacts with CHRYSIN

      Some types of cancer are affected by hormones in the body. Estrogen sensitive cancers are cancers that are affected by estrogen levels in the body. Medications for estrogen sensitive cancers help decrease estrogen in the body. Chrysin might also decrease estrogen in the body. Taking chrysin along with medications for estrogen sensitive cancers might decrease estrogen in the body too much.
      Some medications for estrogen sensitive cancers include aminoglutethimide (Cytadren), anastrozole (Arimidex), exemestane (Aromasin), letrozole (Femara), and others.

    Minor Interaction Be watchful with this combination

    • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with CHRYSIN

      Some medications are changed and broken down by the liver.
      Chrysin might decrease how quickly the liver breaks down some medications. Taking chrysin along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking chrysin talk to your healthcare provider if you take any medications that are changed by the liver.
      Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

    • Medications changed by the liver (Glucuronidated Drugs) interacts with CHRYSIN

      The body breaks down some medications to get rid of them. The liver helps break down these medications. Chrysin might increase how quickly some medications are changed by the liver. This could decrease how well some of these medications work.
      Some of these medications changed by the liver include acetaminophen, atorvastatin (Lipitor), diazepam (Valium), digoxin, entacapone (Comtan), estrogen, irinotecan (Camptosar), lamotrigine (Lamictal), lorazepam (Ativan), lovastatin (Mevacor), meprobamate, morphine, oxazepam (Serax), and others.

    CHRYSIN Dosing

    The appropriate dose of chrysin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chrysin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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    Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

    This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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