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    Other Names:

    Bis-pantothenamidoethyl disulfide, D-bis-(N-Pantothenyl-B-aminoethyl)-disulfide, D-Pantethine, D-Pantéthine, Pantéthine, Pantetheine, Pantethine Octahydrate, Pantetina, Pantomin, Pantosin.

    PANTETHINE Overview
    PANTETHINE Side Effects
    PANTETHINE Interactions
    PANTETHINE Overview Information

    Pantethine is a dietary supplement that is related to vitamin B5 (pantothenic acid).

    Pantethine is used for lowering cholesterol, preventing inflammation, boosting the activity of the immune system, treating an inherited condition called cystinosis, treating gastrointestinal (GI) diseases, and improving athletic performance. It is also used for improving energy, lowering the risk of heart attack and stroke, improving adrenal function, protecting against mental and physical stress, and preventing allergy symptoms in people who are allergic to formaldehyde.

    How does it work?

    Pantethine might increase the concentrations of chemicals that lower blood cholesterol and triglycerides.

    PANTETHINE Uses & Effectiveness What is this?

    Possibly Effective for:

    • Lowering blood fats such as cholesterol and triglycerides, but only modestly. While not all research findings agree, taking pantethine by mouth or as a shot might slightly lower triglycerides, total cholesterol, and “bad” low-density lipoprotein (LDL) cholesterol; as well as raise “good” high-density lipoprotein (HDL) cholesterol. Pantethine also appears to correct blood fat problems that often occur in kidney failure patients who are undergoing hemodialysis.

    Insufficient Evidence for:

    • Athletic performance. Some research suggests that taking pantethine in combination with pantothenic acid and thiamine (given as allithiamin) does not improve muscular strength or endurance in well-trained athletes.
    • Treating cystinosis, an inherited disease. Early research suggests that pantethine might be beneficial for cystinosis.
    • Reducing risk of heart and circulatory disease.
    • Improving function of the adrenal gland.
    • Preventing allergy symptoms in people allergic to formaldehyde.
    • Other conditions.
    More evidence is needed to rate the effectiveness of pantethine for these uses.

    PANTETHINE Side Effects & Safety

    Taking pantethine by mouth is POSSIBLY SAFE for most people for up to a year. Pantethine can cause nausea, diarrhea, and stomach discomfort.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking pantethine if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

    Bleeding disorders: There is some evidence that pantethine can slow blood clotting, so some healthcare providers worry that pantethine might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, get your healthcare provider’s advice before starting pantethine.

    Surgery: Pantethine might slow blood clotting. There is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.

    PANTETHINE Interactions What is this?

    Moderate Interaction Be cautious with this combination

    • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PANTETHINE

      Pantethine might slow blood clotting. Taking pantethine along with medications that also slow clotting might increase the chances of bruising and bleeding.
      Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.


    The following doses have been studied in scientific research:


    • For treating too much fat in the blood (hyperlipoproteinemia): 300 mg of pantethine 3 to 4 times daily.

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    Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

    This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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