Overview

Sulforaphane is a chemical that is made when chewing cruciferous vegetables such as broccoli, cauliflower, and broccoli sprouts.

A chemical in these vegetables called glucoraphanin mixes with an enzyme in humans called myrosinase, which produces sulforaphane. Sulforaphane might increase the death of cancer cells and also reduce swelling.

People use sulforaphane for prostate cancer. It is also used for hay fever, autism, asthma, liver disease, sunburn, and many other conditions, but there is no good scientific evidence to support these other uses.

Don't confuse sulforaphane with broccoli or broccoli sprout. These are not the same.

Uses & Effectiveness ?

Possibly Effective for

  • Prostate cancer. Taking sulforaphane by mouth seems to delay increases in prostate specific antigen (PSA) levels in people who have had prostate cancer. Increased is a sign of prostate cancer returning.

Possibly Ineffective for

  • A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). Taking sulforaphane by mouth doesn't seem to help clear H. pylori in people who are already taking standard H. pylori medication.
There is interest in using sulforaphane for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Sulforaphane is commonly consumed in foods. It is possibly safe when used as medicine. Sulforaphane and sulforaphane-rich broccoli extract products have been used safely for up to 6 months. It's usually well-tolerated. Side effects might include heartburn and stomach upset.

Special Precautions and Warnings

When taken by mouth: Sulforaphane is commonly consumed in foods. It is possibly safe when used as medicine. Sulforaphane and sulforaphane-rich broccoli extract products have been used safely for up to 6 months. It's usually well-tolerated. Side effects might include heartburn and stomach upset. Pregnancy and breast-feeding: Sulforaphane is commonly consumed in foods. But there isn't enough reliable information to know if sulforaphane is safe to use in larger amounts as medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Children: Sulforaphane is commonly consumed in foods. But there isn't enough reliable information to know if it is safe to use in larger amounts as medicine.

Seizure Disorder: Seizure has been rarely reported in people with a history of seizures after taking sulforaphane. It is not clear if sulforaphane increases the risk for seizure. Use with caution.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SULFORAPHANE

    Some medications are changed and broken down by the liver. Sulforaphane might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with SULFORAPHANE

    Some medications are changed and broken down by the liver. Sulforaphane might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with SULFORAPHANE

    Some medications are changed and broken down by the liver. Sulforaphane might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Dosing

Sulforaphane is a chemical found in certain vegetables such as broccoli, broccoli sprout, and cauliflower.

As medicine, sulforaphane has most often been used by adults in broccoli sprout extract products and in broccoli compounds containing the chemical glucoraphanin. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.