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    L - ORNITHINE - L - ASPARTATE

    Other Names:

    2,5-diaminopentanoic acid 2-aminobutanedioic acid, L-Ornithin-L-Aspartat, L-ornithine-L-aspartate Salt, LOLA, Ornithine Aspartate, Ornithylaspartate.

    L-ORNITHINE-L-ASPARTATE Overview
    L-ORNITHINE-L-ASPARTATE Uses
    L-ORNITHINE-L-ASPARTATE Side Effects
    L-ORNITHINE-L-ASPARTATE Interactions
    L-ORNITHINE-L-ASPARTATE Dosing
    L-ORNITHINE-L-ASPARTATE Overview Information

    L-ornithine-L-aspartate is a chemical made up of two amino acids, ornithine and aspartic acid, joined together. Most amino acids are used as building blocks to make protein. However, L-ornithine-L-aspartate is not used to make protein but is instead broken down in the body to provide ornithine and aspartic acid.

    L-ornithine-L-aspartate is most commonly used orally and by needle (by IV) for a liver illness that reduces brain function called hepatic encephalopathy. There is limited scientific research that supports other uses of L-ornithine-L-aspartate.

    How does it work?

    L-ornithine-L-aspartate increases levels the ornithine and aspartic acid in the body. These amino acids help to reduce levels of a toxic chemical called ammonia in the blood.

    L-ORNITHINE-L-ASPARTATE Uses & Effectiveness What is this?

    Possibly Effective for:

    • A liver illness that reduces brain function (hepatic encephalopathy). Most research suggests that L-ornithine-L-aspartate helps reduce symptoms of hepatic encephalopathy in patients with a liver disease called cirrhosis. L-ornithine-L-aspartate is taken by mouth or given with a needle. However, not all people who get hepatic encephalopathy have cirrhosis. L-ornithine-L-aspartate might not help reduce symptoms in people with other causes of hepatic encephalopathy.

    Insufficient Evidence for:

    • A liver illness called cirrhosis. Early research suggests that giving L-ornithine-L-aspartate with a needle might decrease levels in the blood of the toxic chemical ammonia. However, it doesn’t seem to help with any other symptoms of cirrhosis.
    • To make people think more clearly during exercise. After exercising for a long time, it is harder to think. Early research suggests that taking L-ornithine-L-aspartate together with other amino acids called branched chain amino acids might help people think faster.
    • For protection when a tube (transjugular intrahepatic portosystemic shunt [TIPSS]) is put in the liver. Some research suggests that giving L-ornithine-L-aspartate with a needle might help people getting this tube think more clearly.
    • Wound healing.
    • To build muscle.
    • Other conditions.
    More evidence is needed to rate L-ornithine-L-aspartate for these uses.


    L-ORNITHINE-L-ASPARTATE Side Effects & Safety

    L-ornithine-L-aspartate is POSSIBLY SAFE when taken by mouth or given with a needle (by IV). Side effects don’t happen very often. However, nausea, vomiting, cough, muscle cramping, and diarrhea have happened in some people getting injections of L-ornithine-L-aspartate.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: Not enough is known about the use of L-ornithine-L-aspartate during pregnancy and breast-feeding. Stay on the safe side and avoid use.

    L-ORNITHINE-L-ASPARTATE Interactions What is this?

    We currently have no information for L-ORNITHINE-L-ASPARTATE Interactions

    L-ORNITHINE-L-ASPARTATE Dosing

    The following doses have been studied in scientific research:

    ADULTS
    BY MOUTH:

    • For a liver illness that reduces brain function (hepatic encephalopathy): 9-18 grams daily for up to 3 months has been used.
    WITH A NEEDLE:
    • For a liver illness that reduces brain function (hepatic encephalopathy): 5-40 grams daily for up to 7 days has been used.

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    Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

    This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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