L-ORNITHINE-L-ASPARTATE Overview Information
L-ornithine-L-aspartate is a chemical made up of two amino acids, ornithine and aspartic acid, joined together. Most amino acids are used as building blocks to make protein. However, L-ornithine-L-aspartate is not used to make protein but is instead broken down in the body to provide ornithine and aspartic acid.
L-ornithine-L-aspartate is most commonly used orally and by needle (by IV) for a liver illness that reduces brain function called hepatic encephalopathy. There is limited scientific research that supports other uses of L-ornithine-L-aspartate.
How does it work?
L-ornithine-L-aspartate increases levels the ornithine and aspartic acid in the body. These amino acids help to reduce levels of a toxic chemical called ammonia in the blood.
Possibly Effective for:
- A liver illness that reduces brain function (hepatic encephalopathy). Most research suggests that L-ornithine-L-aspartate helps reduce symptoms of hepatic encephalopathy in patients with a liver disease called cirrhosis. L-ornithine-L-aspartate is taken by mouth or given with a needle. However, not all people who get hepatic encephalopathy have cirrhosis. L-ornithine-L-aspartate might not help reduce symptoms in people with other causes of hepatic encephalopathy.
- A liver illness called cirrhosis. Early research suggests that giving L-ornithine-L-aspartate with a needle might decrease levels in the blood of the toxic chemical ammonia. However, it doesn’t seem to help with any other symptoms of cirrhosis.
- To make people think more clearly during exercise. After exercising for a long time, it is harder to think. Early research suggests that taking L-ornithine-L-aspartate together with other amino acids called branched chain amino acids might help people think faster.
- For protection when a tube (transjugular intrahepatic portosystemic shunt [TIPSS]) is put in the liver. Some research suggests that giving L-ornithine-L-aspartate with a needle might help people getting this tube think more clearly.
- Wound healing.
- To build muscle.
- Other conditions.
L-ORNITHINE-L-ASPARTATE Side Effects & Safety
L-ornithine-L-aspartate is POSSIBLY SAFE when taken by mouth or given with a needle (by IV). Side effects don’t happen very often. However, nausea, vomiting, cough, muscle cramping, and diarrhea have happened in some people getting injections of L-ornithine-L-aspartate.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of L-ornithine-L-aspartate during pregnancy and breast-feeding. Stay on the safe side and avoid use.
The following doses have been studied in scientific research:
- For a liver illness that reduces brain function (hepatic encephalopathy): 9-18 grams daily for up to 3 months has been used.
- For a liver illness that reduces brain function (hepatic encephalopathy): 5-40 grams daily for up to 7 days has been used.