PALMITOYLETHANOLAMIDE PEA Overview Information
Palmitoylethanolamide is a chemical made from fat. It is found naturally in foods such as egg yolks and peanuts, and in the human body. It is also used as a medicine.
Palmitoylethanolamide is used for pain, neuropathic pain, fibromyalgia, multiple sclerosis (MS), carpal tunnel syndrome, infections of the airway, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work?
Palmitoylethanolamide is a chemical that can bind to cells in the body and reduce pain and swelling.
Possibly Effective for:
- Pain. Some research shows that taking a specific type of palmitoylethanolamide (Normast, Epitech Group) can reduce pain in people with chronic pain due to various causes.
Possibly Ineffective for:
- A muscle control disorder marked by involuntary movements and muscle tightness (spasticity). Research shows that taking palmitoylethanolamide does not reduce spasticity of the spine or help with sleep problems in people with spinal cord injury.
- Lou Gehrig's disease (amyotrophic lateral sclerosis, ALS). In people with ALS, early research shows that taking palmitoylethanolamide with the medication riluzole might improve how well the lungs work.
- Carpal tunnel syndrome. Early research suggests that taking palmitoylethanolamide might reduce some of the pain and discomfort of carpal tunnel syndrome.
- Nerve pain in people with diabetes (diabetic neuropathy). Early research shows that taking palmitoylethanolamide might reduce nerve pain in people with diabetic neuropathy.
- Fibromyalgia. Early research in patients with fibromyalgia suggests that adding palmitoylethanolamide to other standard medications for fibromyalgia might help to reduce pain.
- A group of eye disorders that can lead to vision loss (glaucoma). Glaucoma is caused by high pressure in the eye. Palmitoylethanolamide seems to reduce intraocular pressure in people with glaucoma or at risk of glaucoma. It also seems to reduce intraocular pressure in people that had surgery to prevent glaucoma.
- Multiple sclerosis (MS). Early research shows that taking palmitoylethanolamide might help improve symptoms in people with MS who are receiving treatment with the medication interferon-beta1a. However, there are now better medications available to treat MS. It is not known if taking palmitoylethanolamide along with using these newer medications would be helpful.
- Nerve pain. There are some reports of people having less nerve pain when they take palmitoylethanolamide. However, high-quality research is mixed. Some research in large groups of people show that taking palmitoylethanolamide might reduce pain in people with sciatica. But it might be less effective in people with nerve pain due to injury to the spine. More research is needed to clarify if palmitoylethanolamide is helpful for people with different kinds of nerve pain.
- Pain after surgery. Early research suggests that taking a specific type of palmitoylethanolamide might reduce pain after having a tooth removed.
- Infection of the airways. Some early research shows that taking palmitoylethanolamide might reduce the risk of developing a lung infection in adults and children. But not all research agrees.
- A group of painful conditions that affect the jaw joint and muscle (temporomandibular disorders or TMD). Early research shows that taking palmitoylethanolamide might reduce pain and allow the mouth to open better in people with arthritis of the jaw joint.
- Illness from a Shigella bacteria infection (shigellosis).
- A painful uterine disorder (endometriosis).
- Eye conditions.
- Long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD).
- Kidney disease.
- Vulvar pain.
- Weight loss.
- Withdrawal from marijuana.
- Dry skin.
PALMITOYLETHANOLAMIDE PEA Side Effects & Safety
When taken by mouth: Taking palmitoylethanolamide is POSSIBLY SAFE for most adults when used for up to 3 months. Possible side effects, such as upset stomach, are very rare. There isn't enough reliable information to know if palmitoylethanolamide is safe to use for longer than 3 months.
When applied to the skin: There isn't enough reliable information to know if palmitoylethanolamide is safe to use or what the side effects might be.
Special Precautions & Warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if palmitoylethanolamide is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.
PALMITOYLETHANOLAMIDE PEA Dosing
The following doses have been studied in scientific research:
- Pain: Palmitoylethanolamide 300-1,200 mg daily for up to 60 days.