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    Other Names:

    2-Oxopropanoate, 2-Oxopropanoic acid, 2-Oxypropanoic Acid, Acetylformic Acid, Acide Acétylformique, Acide Alpha-Kéto, Acide Oxo-2 Propanoïque, Acide Pyruvique, Alpha-Keto Acid, Alpha-Ketopropionic Acid, Calcium Pyruvate, Calcium Pyruvate Monohyd...
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    PYRUVATE Overview
    PYRUVATE Side Effects
    PYRUVATE Interactions
    PYRUVATE Dosing
    PYRUVATE Overview Information

    The body produces pyruvate when it breaks down sugar (glucose). Pyruvate is available as a supplement.

    Pyruvate is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.

    Some people apply pyruvic acid, a liquid form of pyruvate, to the skin to reduce wrinkles and other signs of aging. Pyruvic acid is sometimes applied to the skin as a facial peel.

    How does it work?

    Pyruvate might contribute to weight loss by increasing the breakdown of fat.

    In addition, pyruvic acid seems to cause the outer layer of skin cells to slough off, which accounts for its use in reversing aging due to exposure to the sun.

    PYRUVATE Uses & Effectiveness What is this?

    Possibly Effective for:

    • Aging skin. Applying a 50% pyruvic acid skin peel once a week for 4 weeks seems to smooth skin, decrease wrinkles, and decrease dark spots associated with aging due to sun exposure.

    Insufficient Evidence for:

    • Alcohol-related liver disease. Early research suggests that giving sodium pyruvate intravenously (by IV) for 25 days improves measures of liver function in people with alcohol-related liver disease.
    • Long term lung disease (chronic obstructive pulmonary disease, COPD). Early research shows that inhaling sodium pyruvate using a nebulizer for 6 weeks may improve lung function in people with COPD.
    • Congestive heart failure (CHF). Early research suggests that injecting pyruvate into the artery that feeds blood into the heart may improve symptoms and heart function in people with heart failure.
    • Coronary artery bypass graft (CABG) surgery. Early research suggests that adding pyruvate to a solution that is used to help stop the heart during a CABG surgery improves recovery and may reduce heart complications after surgery.
    • Scaly, flaky skin (ichthyosis). Early research suggests that topically applying a Eucerin skin cream containing 5% pyruvate for at least 2 weeks helps increase skin shedding in people with scaly, flaky skin.
    • Weight loss and obesity. So far, early studies disagree about the effectiveness of pyruvate for weight loss. Some results show pyruvate may help increase weight loss and decrease body fat, while other results show no effect.
    • Cataracts.
    • Cancer.
    • Other conditions.
    More evidence is needed to rate the effectiveness of pyruvate for these uses.

    PYRUVATE Side Effects & Safety

    Pyruvate is POSSIBLY SAFE when taken by mouth or inhaled using a nebulizer for up to six weeks. Side effects such as stomach upset, gas, bloating, and diarrhea can occur when large amounts are taken.

    Pyruvic acid facial peels are POSSIBLY SAFE when applied by a healthcare professional. It can cause severe skin burning and should be applied only to small patches of skin at a time.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking pyruvate if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

    A heart condition called cardiomyopathy: One death was associated with intravenous use in a child who had cardiomyopathy.

    Diarrhea: Taking high amounts of pyruvate by mouth might worsen diarrhea.

    Irritable bowel syndrome (IBS): Taking high amounts of pyruvate by mouth might worsen symptoms of IBS.

    PYRUVATE Interactions What is this?

    We currently have no information for PYRUVATE Interactions

    PYRUVATE Dosing

    The following doses have been studied in scientific research:


    • For aging skin: A 50% pyruvic acid peel applied once weekly for 4 weeks.

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    Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

    This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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