4-androstene-3,6,17-trione, 6-OXO, ADT, Androst-4- ene-3,6,17-trione, Androstenetriona, Androsténétrione.


Overview Information

Androstenetrione is a steroid. Despite serious safety concerns, it is used for improving athletic performance.

Androstenetrione is promoted as an alternative to “prohormones” such as androstenedione. Marketers claim that androstenetrione increases the body's natural testosterone levels and therefore is free from the negative side effects of prohormones. There is no reliable evidence to back these claims.

How does it work?

The body converts some of the male hormone testosterone to the female hormone estrogen. Androstenetrione blocks this conversion. Some people suggest that the body makes up for the falling estrogen level by making more testosterone. They further suggest that the higher levels of testosterone will improve athletic performance. Some people who sell androstenetrione say that it increases total testosterone by 188% and free testosterone by 226% over 3 weeks of use. But there is no scientifically reliable research in people that supports these claims.


Uses & Effectiveness?

Insufficient Evidence for

  • Improving athletic performance.
  • Other conditions.
More evidence is needed to rate the effectiveness of androstenetrione for these uses.

Side Effects

Side Effects & Safety

Androstenetrione might be UNSAFE for anyone. If it actually increases testosterone levels in the body, the extra testosterone could cause serious side effects including liver problems, heart problems, and cancer. Avoid using androstenetrione.

Special Precautions & Warnings:

It might be UNSAFE for anyone to use androstenetrione, but people with the following conditions have extra reasons to avoid use.

Pregnancy and breast-feeding: Not enough is known about the use of androstenetrione during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Prostate cancer and other hormone-sensitive cancers: Androstenetrione might increase testosterone levels. Men with hormone-sensitive conditions such as prostatecancer should avoid using androstenetrione.

Liver disease: Androstenetrione might increase testosterone levels. Increased testosterone is associated with liver problems. If you have liver disease, don’t take androstenetrione. If you have taken androstenetrione, it would be a good idea to have liver function tests (LFTs) done.



We currently have no information for ANDROSTENETRIONE Interactions.



The appropriate dose of androstenetrione depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for androstenetrione. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Covey DF, Hood WF. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology 1981;108:1597-9. View abstract.
  • Numazawa M, Mutsumi A, Asano N, Ito Y. A time-dependent inactivation of aromatase by 19-substituted androst-4-ene-3,6,,17-triones. Steroids 1993;58:40-6. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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