Acide Aspartique, Acide L-Aspartique, Asparatate Chelated Minerals, Aspartate Mineral Chelates, Aspartate de Potassium, Aspartatos, Aspartic Acid, D-Aspartic Acid, L-Aspartate, L-Aspartic Acid, Mineral Aspartates, N-Methyl-D-Aspartic Acid, Potassium Aspartate.<br/><br/>


Overview Information

Aspartate is a vitamin-like substance called an amino acid. As a dietary supplement, aspartate is combined with minerals and is available as copper aspartate, iron aspartate, magnesium aspartate, manganese aspartate, potassium aspartate, and zinc aspartate.

Aspartates are used to increase absorption of the minerals they are combined with and to enhance athletic performance. Some forms are used to reduce brain damage caused by cirrhosis of the liver (hepatic encephalopathy) when given intravenously by a healthcare professional.

How does it work?

There isn't enough information to know how aspartates work.


Uses & Effectiveness?

Insufficient Evidence for

  • Liver cirrhosis. Developing research suggests L-ornithine-L-aspartate given by IV (intravenously) might reduce brain damage in some patients with liver cirrhosis.
  • Enhancing athletic performance.
  • Increasing mineral levels. So far there is not evidence that aspartates increase mineral absorption. Except in cases of mineral deficiency, such as iron-deficiency anemia, a well-balanced diet typically provides the recommended daily allowance (RDA) of minerals.
  • Other conditions.
More evidence is needed to rate the effectiveness of aspartates for these uses.

Side Effects

Side Effects & Safety

It is not known if aspartates are safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of aspartates during pregnancy and breast-feeding. Stay on the safe side and avoid use.



We currently have no information for ASPARTATES Interactions.



The appropriate dose of aspartates depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for aspartates. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Abel, T., Knechtle, B., Perret, C., Eser, P., von Arx, P., and Knecht, H. Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism - a randomized, double-blind, placebo-controlled study. Int J Sports Med 2005;26(5):344-349. View abstract.
  • Colombani, P. C., Bitzi, R., Frey-Rindova, P., Frey, W., Arnold, M., Langhans, W., and Wenk, C. Chronic arginine aspartate supplementation in runners reduces total plasma amino acid level at rest and during a marathon run. Eur J Nutr. 1999;38(6):263-270. View abstract.
  • Denis, C., Dormois, D., Linossier, M. T., Eychenne, J. L., Hauseux, P., and Lacour, J. R. Effect of arginine aspartate on the exercise-induced hyperammoniemia in humans: a two periods cross-over trial. Arch.Int Physiol Biochim.Biophys. 1991;99(1):123-127. View abstract.
  • FORMICA, P. E. The housewife syndrome. Treatment with the potassium and magnesium salts of aspartic acid. Curr.Ther.Res.Clin.Exp. 1962;4:98-106. View abstract.
  • Franzoni, F., Mataloni, E., Femia, R., and Galetta, F. Effect of oral potassium supplementation on QT dispersion in anorexia nervosa. Acta Paediatr. 2002;91(6):653-656. View abstract.
  • HICKS, J. T. TREATMENT OF FATIGUE IN GENERAL PRACTICE: A DOUBLE BLIND STUDY. Clin.Med (Northfield.Il) 1964;71:85-90. View abstract.
  • Kirk, S. J., Hurson, M., Regan, M. C., Holt, D. R., Wasserkrug, H. L., and Barbul, A. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993;114(2):155-159. View abstract.
  • NAGLE, F. J., BALKE, B., GANSLEN, R. V., and DAVIS, A. W., Jr. THE MITIGATION OF PHYSICAL FATIGUE WITH "SPARTASE". REP 63-12. Rep.Civ.Aeromed.Res.Inst.US. 1963;1-10. View abstract.
  • Ruddel, H., Werner, C., and Ising, H. Impact of magnesium supplementation on performance data in young swimmers. Magnes.Res 1990;3(2):103-107. View abstract.
  • SHAW, D. L., Jr., CHESNEY, M. A., TULLIS, I. F., and AGERSBORG, H. P. Management of fatigue: a physiologic approach. Am.J Med Sci. 1962;243:758-769. View abstract.
  • Trudeau, F. and Murphy, R. Effects of potassium-aspartate salt administration on glycogen use in the rat during a swimming stress. Physiol Behav. 1993;54(1):7-12. View abstract.
  • Trudeau, F. Aspartate and its ergogenic potential. Science & Sports 1996;11(4):223-232.
  • Tuttle, J. L., Potteiger, J. A., Evans, B. W., and Ozmun, J. C. Effect of acute potassium-magnesium aspartate supplementation on ammonia concentrations during and after resistance training. Int J Sport Nutr. 1995;5(2):102-109. View abstract.
  • Beltz SD, Doering PL. Efficacy of nutritional supplements used by athletes. Clin Pharm 1993;12:900-8. View abstract.
  • Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res 2001;14:257-62.. View abstract.
  • Rees C, Oppong K, Mardini H, et al. Effect of L-Ornithine-L-Aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Gut 2000;47:571-4.. View abstract.
  • Wagenmakers A. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc Sport Sci Rev 1998;26:287-314. View abstract.
  • Witteman JC, Grobbee DE, Derkx FH, et al. Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension. Am J Clin Nutr 1994;60:129-35. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.