1: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

1,3-DMBA is a chemical that might have stimulant effects. 1,3-DMBA is used for athletic performance, memory and thinking skills (cognitive function), and obesity, but there is no good scientific evidence to support these uses. Using 1,3-DMBA might also be unsafe.

1,3-DMBA is found in small amounts in some plants. However, some supplements have been found to contain much larger amounts than are found in nature. Because of this, there is concern that manufacturers are using synthetic 1,3-DMBA that is made in a laboratory rather than obtaining it from a natural source. The US Food and Drug Administration (FDA) states that supplements containing 1,3-DMBA are not legal and cannot be sold in the US. 1,3-DMBA is also included in the World Anti-Doping Agency's prohibited substances list. Competitive athletes should avoid taking it.

How does it work ?

1,3-DMBA is thought to have stimulant effects. In animals, it causes blood vessels to contract, which increases blood pressure and speeds up the heart.

View References

REFERENCES:

Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.

Cohen PA, Travis JC, and Venhuis BJ. A synthetic stimulant never tested in humans, 1,3-dimethylbutylamine (DMBA), is identified in multiple dietary supplements. Drug Test Analysis.,10-8-2014.

Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.

FDA challenges marketing of DMAA products for lack of safety evidence. US Food and Drug Administration, April 27, 2012. Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302133.htm

Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7. View abstract.

Material Safety Data Sheet. 1,3-Dimethylbutylamine, 98%. https://www.fishersci.ca/viewmsds.do?catNo=AC314700050.

McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.

McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31.

Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: https://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).

SWANSON EE, CHEN KK. Comparison of pressor action of alicyclic derivatives of aliphatic amines. J Pharmacol Exp Ther. 1948 Aug;93(4):423-9. View abstract.

. Food and Drug Administration. DMBA in dietary supplements. https://www.fda.gov/food/dietary-supplement-products-ingredients/dmba-dietary-supplements. Updated November 29, 2017. Accessed November 16, 2019.

Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.

Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. View abstract.

Cohen PA, Travis JC, and Venhuis BJ. A synthetic stimulant never tested in humans, 1,3-dimethylbutylamine (DMBA), is identified in multiple dietary supplements. Drug Test Analysis.,10-8-2014.

Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA). Clin Toxicol (Phila) 2018;56(6):421-6. View abstract.

Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med. 2012 Dec;177(12):1455-9. View abstract.

Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7. View abstract.

Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. View abstract.

Material Safety Data Sheet. 1,3-Dimethylbutylamine, 98%. https://www.fishersci.ca/viewmsds.do?catNo=AC314700050.

McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.

McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31.

Palmer PG Jr. Deadly dimethylamylamine: "health" supplements are killing consumers while current regulations impede FDA action. J Leg Med. 2014;35(2):311-36. View abstract.

Starling S. Synthetic geranium substance raises ephedra-like red flags. Nutraingredients-use.com, May 11, 2010. Available at: https://www.nutraingredients-usa.com/Industry/Synthetic-geranium-substance-raises-ephedra-like-red-flags. (Accessed 12 August 2011).

SWANSON EE, CHEN KK. Comparison of pressor action of alicyclic derivatives of aliphatic amines. J Pharmacol Exp Ther. 1948 Aug;93(4):423-9. View abstract.

Vorce SP, Holler JM, Cawrse BM, Magluilo J. Dimethylamylamine: A drug causing positive immunoassay results for amphetamines. J Anal Toxicol 2011;35:183-7. View abstract.

World Anti-Doping Agency. Prohibited list - January 2019. Available at: https://www.wada-ama.org/sites/default/files/wada_2019_english_prohibited_list.pdf. Accessed September 24, 2019.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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1,3-DMBA

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