FULVIC ACID: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Fulvic acid is a group of chemicals that forms when plants and animals break down. It's found in humus (organic matter) of soil, peat, streams, and lakes.

Fulvic acid might block reactions in the body that cause allergy symptoms. It might also reduce swelling and prevent or slow the growth of cancer.

People use fulvic acid for hay fever, Alzheimer disease, eczema, cancer, fatigue, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for FULVIC ACID overview.

Side Effects

When taken by mouth: Fulvic acid is possibly safe when used for up to 7 days. It seems to be well-tolerated. Side effects might include diarrhea, headache, and sore throat.

When applied to the skin: Fulvic acid is possibly safe when used for up to 4 weeks.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if fulvic acid is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Autoimmune diseases: Fulvic acid might increase the activity of the immune system. This might worsen some autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA).

Kashin-Beck Disease: Fulvic acid in drinking water might increase the risk of developing Kashin-Beck bone disease. It is thought that the risk is greatest in regions where people do not receive enough selenium in their diet.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with FULVIC ACID
Fulvic acid might slow blood clotting. Taking fulvic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications that decrease the immune system (Immunosuppressants) interacts with FULVIC ACID
Fulvic acid can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking fulvic acid along with these medications might decrease the effects of these medications.
Thyroid hormone interacts with FULVIC ACID
Fulvic acid affects thyroid hormone levels. Taking fulvic acid with thyroid hormone might interfere with therapy to make thyroid function normal.

Dosing

There isn't enough reliable information to know what an appropriate dose of fulvic acid might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Carrasco-Gallardo, C, Guzman, L, and Maccioni, RB. Shilajit: a natural phytocomplex with potential procognitive activity. Int J Alzheimers Dis. 2012;2012:674142. View abstract.

Cornejo, A, Jimenez, JM, Caballero, L, Melo, F, Maccioni, RB. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. J Alzheimers Dis 2011;27(1):143-153. View abstract.

Corsaro, A, Anselmi, C, Polano, M, Aceto, A, Florio, T, De, Nobili M. The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization. J Biol Regul Homeost Agents 2010;24(1):27-39. View abstract.

Junek, R, Morrow, R, Schoenherr, JI, Schubert, R, Kallmeyer, R, Phull, S, Klocking, R. Bimodal effect of humic acids on the LPS-induced TNF-alpha release from differentiated U937 cells. Phytomedicine 2009;16(5):470-476. View abstract.

Kotwal, GJ. Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs). Vaccine 6-6-2008;26(24):3055-3058. View abstract.

Lindsey, ME, Tarr, MA. Quantitation of hydroxyl radical during fenton oxidation following a single addition of iron and peroxide. Chemosphere 2000;41(3):409-417. View abstract.

Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. View abstract.

Peng, A, Wang, WH, Wang, CX, Wang, ZJ, Rui, HF, Wang, WZ, and Yang, ZW. The role of humic substances in drinking water in Kashin-Beck disease in China. Environ Health Perspect. 1999;107(4):293-296. View abstract.

Peng, A, Xu, LQ. The effects of humic acid on the chemical and biological properties of selenium in the environment. Sci Total Environ. 1987;64(1-2):89-98. View abstract.

Peng, A, Yang, C, Rui, H, Li, H. Study on the pathogenic factors of Kashin-Beck disease. J Toxicol Environ Health 1992;35(2):79-90. View abstract.

Peng, A, Yang, CL. Examination of the roles of selenium in the Kaschin-Beck disease. Cartilage cell test and model studies. Biol Trace Elem Res 1991;28(1):1-9. View abstract.

Pittayakhajonwut, P, Dramae, A, Intaraudom, C, Boonyuen, N, Nithithanasilp, S, Rachtawee, P, Laksanacharoen, P. Two new drimane sesquiterpenes, fudecadiones A and B, from the soil fungus Penicillium sp. BCC 17468. Planta Med 2011;77(1):74-76. View abstract.

Sobsey, MD, Hickey, AR. Effects of humic and fulvic acids on poliovirus concentration from water by microporous filtration. Appl Environ Microbiol. 1985;49(2):259-264. View abstract.

Sudre, P, Mathieu, F. Kashin-Beck disease: from etiology to prevention or from prevention to etiology? Int Orthop. 2001;25(3):175-179. View abstract.

van Rensburg, CE, van, Straten A, Dekker, J. An in vitro investigation of the antimicrobial activity of oxifulvic acid. J Antimicrob Chemother. 2000;46(5):853.View abstract.

Verma, S, Singh, A, and Mishra, A. The effect of fulvic acid on pre- and postaggregation state of Abeta(17-42): molecular dynamics simulation studies. Biochim Biophys Acta 2013;1834(1):24-33. View abstract.

Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. View abstract.

Wang, C, Wang, Z, Peng, A, Hou, J, Xin, W. Interaction between fulvic acids of different origins and active oxygen radicals. Sci China C Life Sci 1996;39(3):267-275. View abstract.

Weber JH, Wilson SA. The isolation and characterization of fulvic acid and humic acid from river water. Water Res 1975;9(12)1079-1084.

Yamada, P, Isoda, H, Han, JK, Talorete, TP, Abe, Y. Inhibitory effect of fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells. Biosci Biotechnol Biochem 2007;71(5):1294-1305. View abstract.

Yang C, Niu C, Bodo M, et al. Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease. Biochem J. 1993;289 (Pt 3):829-35. View abstract.

Yang, CL, Bodo, M, Notbohm, H, Peng, A, Muller, PK. Fulvic acid disturbs processing of procollagen II in articular cartilage of embryonic chicken and may also cause Kashin-Beck disease. Eur J Biochem 12-18-1991;202(3):1141-1146. View abstract.

Carrasco-Gallardo, C, Guzman, L, and Maccioni, RB. Shilajit: a natural phytocomplex with potential procognitive activity. Int J Alzheimers Dis. 2012;2012:674142. View abstract.

Gandy JJ, Meeding JP, Snyman JR, et al. Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid. Clin Pharmacol. 2012;4:7-11. View abstract.

Gandy JJ, Snyman JR, van Rensburg CE. Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in topical treatment of eczema. Clin Cosmet Investig Dermatol. 2011;4:145-8. View abstract.

Lindsey, ME, Tarr, MA. Quantitation of hydroxyl radical during fenton oxidation following a single addition of iron and peroxide. Chemosphere 2000;41(3):409-417. View abstract.

Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. View abstract.

Peng, A, Xu, LQ. The effects of humic acid on the chemical and biological properties of selenium in the environment. Sci Total Environ. 1987;64(1-2):89-98. View abstract.

Peng, A, Yang, C, Rui, H, Li, H. Study on the pathogenic factors of Kashin-Beck disease. J Toxicol Environ Health 1992;35(2):79-90. View abstract.

Peng, A, Yang, CL. Examination of the roles of selenium in the Kaschin-Beck disease. Cartilage cell test and model studies. Biol Trace Elem Res 1991;28(1):1-9. View abstract.

Samiee-Rad F, Hosseini Sedighi SF, Taherkhani A, Gheibi N. Evaluation of Healing Effects of Poultice Containing 0.5% Fulvic Acid on Male White-Male Rats with Skin Ulcer. J Cutan Aesthet Surg 2022;15(1):40-47. View abstract.

Sobsey, MD, Hickey, AR. Effects of humic and fulvic acids on poliovirus concentration from water by microporous filtration. Appl Environ Microbiol. 1985;49(2):259-264. View abstract.

Sudre, P, Mathieu, F. Kashin-Beck disease: from etiology to prevention or from prevention to etiology? Int Orthop. 2001;25(3):175-179. View abstract.

van Rensburg, CE, van, Straten A, Dekker, J. An in vitro investigation of the antimicrobial activity of oxifulvic acid. J Antimicrob Chemother. 2000;46(5):853.View abstract.

Wang, C, Wang, Z, Peng, A, Hou, J, Xin, W. Interaction between fulvic acids of different origins and active oxygen radicals. Sci China C Life Sci 1996;39(3):267-275. View abstract.

Weber JH, Wilson SA. The isolation and characterization of fulvic acid and humic acid from river water. Water Res 1975;9(12)1079-1084.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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