ALPHA-KETOGLUTARATE
A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d'Arginine, Alpha-Cétoglutarate de Calcium, Alpha-Cétoglutarate de Créatine, Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha KG, AAKG, AKG, Arginine Alpha-Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Oxoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoglutaric Acid, 2-Oxopentanedoicic Acid.<br/><br/>
Uses & Effectiveness
Possibly Effective for
- Improving kidney failure treatment (hemodialysis). Taking calcium alpha-ketoglutarate seems to improve results of certain lab tests used to monitor the effectiveness of hemodialysis in patients receiving this treatment.
- Preventing blood supply problems during heart surgery. Administering alpha-ketoglutarate intravenously (by IV) seems to reduce blood supply problems during heart surgery.
- Preventing muscle breakdown. Alpha-ketoglutarate seems to reduce muscle breakdown after surgery or trauma.
Insufficient Evidence for
- Athletic performance. A small study found that taking alpha-ketoglutarate daily for 5 weeks improves athletic performance.
- Bacterial infections.
- Bone health.
- Cataracts.
- Intestinal and stomach disorders.
- Kidney disease.
- Lung health.
- Yeast infections.
- Other conditions.
Interactions
We currently have no information for ALPHA-KETOGLUTARATE Interactions.
Dosing
The following doses have been studied in scientific research:
BY MOUTH:
- For patients undergoing hemodialysis: 1.187 grams of alpha-ketoglutarate plus 0.813 grams of calcium carbonate three times weekly has been used. Also, about 4.5 grams of calcium alpha-ketoglutarate has been used daily for 3 years.
- For preventing muscle breakdown: Healthcare providers give alpha-ketoglutarate down a tube.
- For preventing blood supply problems during heart surgery and for preventing muscle breakdown after surgery or trauma: Healthcare providers give alpha-ketoglutarate intravenously (by IV).
REFERENCES:
- Hammarqvist, F., Wernerman, J., von der, Decken A., and Vinnars, E. Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery. Surgery 1991;109(1):28-36. View abstract.
- Mason, G. F., Gruetter, R., Rothman, D. L., Behar, K. L., Shulman, R. G., and Novotny, E. J. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J.Cereb.Blood Flow Metab 1995;15(1):12-25. View abstract.
- Riedel, E., Hampl, H., Steudle, V., and Nundel, M. Calcium alpha-ketoglutarate administration to malnourished hemodialysis patients improves plasma arginine concentrations. Miner.Electrolyte Metab 1996;22(1-3):119-122. View abstract.
- Salerno, F., Abbiati, R., and Fici, F. Effect of pyridoxine alpha-ketoglutarate (PAK) on ammonia and pyruvic and lactic acid blood levels in patients with cirrhosis. Int.J.Clin.Pharmacol.Res. 1983;3(1):21-25. View abstract.
- Son, E. D., Choi, G. H., Kim, H., Lee, B., Chang, I. S., and Hwang, J. S. Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice. Biol.Pharm.Bull. 2007;30(8):1395-1399. View abstract.
- Wiren, M., Permert, J., and Larsson, J. Alpha-ketoglutarate-supplemented enteral nutrition: effects on postoperative nitrogen balance and muscle catabolism. Nutrition 2002;18(9):725-728. View abstract.
- Zimmermann, E., Wassmer, S., and Steudle, V. Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism. Miner.Electrolyte Metab 1996;22(1-3):196-199. View abstract.
- Aussel C, Coudray-Lucas C, Lasnier E, et al. Alpha-Ketoglutarate uptake in human fibroblasts. Cell Biol Int 1996;20:359-63. View abstract.
- Blomqvist BI, Hammarqvist F, von der Decken A, et al. Glutamine and alpha-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. Metabolism 1995;44:1215-22. View abstract.
- Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine and alpha-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. Metabolism 1995;44:1215-22. View abstract.
- Jeppsson A, Ekroth R, Friberg P, et al. Renal effects of alpha-ketoglutarate early after coronary operations. Ann Thorac Surg 1998;65:684-90. View abstract.
- Kjellman U, Bjork K, Ekroth R, et al. Alpha-ketoglutarate for myocardial protection in heart surgery. Lancet 1995;345:552-3. View abstract.
- Kjellman UW, Bjork K, Ekroth R, et al. Addition of alpha-ketoglutarate to blood cardioplegia improves cardioprotection. Ann Thorac Surg 1997;63:1625-33. View abstract.
- Liu Y, Lange R, Langanky J, et al. Improved training tolerance by supplementation with a-keto acids in untrained young adults: a randomized, double-blind, placebo-controlled trial. Journal of the International Society of Sports Nutrition 2012;9:37. View abstract.
- Riedel E, Nundel M, Hampl H. Alpha-Ketoglutarate application in hemodialysis patients improves amino acid metabolism. Nephron 1996;74:261-5. View abstract.
- Wernerman J, Hammarqvist F, Vinnars E. Alpha-ketoglutarate and postoperative muscle catabolism. Lancet 1990;335:701-3. View abstract.
- Willoughby DS, Boucher T, Reid J, Skelton G, Clark M. Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise. Int J Sport Nutr Exerc Metab. 2011 Aug;21(4):291-9. View abstract.
- Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016 Jan;24(1):1-8. View abstract.