Agmatine is a chemical found in bacteria, plants, and animals, including humans. It is made from the amino acid known as arginine.

Agmatine is commonly used by mouth for depression, nerve pain, improving athletic performance, and many more conditions. But there is limited scientific research to support any of these uses.

How does it work ?

Agmatine seems to help manage different chemicals and pathways in the brain. This might improve certain conditions of the brain and nervous system.

Uses & Effectiveness ?

Insufficient Evidence for

  • Herniated disc. Early research shows that taking agmatine might decrease pain and increase quality of life in people with nerve pain due to a herniated disc.
  • Alcohol use disorder.
  • Alzheimer disease.
  • Anxiety.
  • Athletic performance.
  • Autism.
  • Bipolar disorder.
  • Depression.
  • Nerve pain.
  • Parkinson disease.
  • Seizures.
  • Schizophrenia.
  • Stroke.
  • Other conditions.
More evidence is needed to rate agmatine for these uses.

Side Effects

There isn't enough reliable information to know if agmatine is safe. Some people taking agmatine have had side effects such as diarrhea, upset stomach, and nausea.

Special Precautions and Warnings

There isn't enough reliable information to know if agmatine is safe. Some people taking agmatine have had side effects such as diarrhea, upset stomach, and nausea. Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking agmatine if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Diabetes: Agmatine might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use agmatine.

Surgery: Agmatine might lower blood sugar and blood pressure and could interfere with blood sugar and blood pressure control during and after surgery. Stop taking agmatine at least 2 weeks before a scheduled surgery.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Medications for diabetes (Antidiabetes drugs) interacts with AGMATINE

    Agmatine might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking agmatine along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

  • Medications for high blood pressure (Antihypertensive drugs) interacts with AGMATINE

    Using agmatine with drugs that lower blood pressure may increase the effects of these drugs and may lower blood pressure too much.
    Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.


The appropriate dose of agmatine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for agmatine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.