Overview
5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, pain, and mood.
People use Griffonia simplicifolia seeds for anxiety, depression, headache, insomnia, motion sickness, stress, obesity, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse Griffonia simplicifolia with 5-HTP, the main chemical in Griffonia simplicifolia seeds. These are not the same.
Uses & Effectiveness
We currently have no information for GRIFFONIA SIMPLICIFOLIA overview.
Side Effects
Special Precautions and Warnings
Pregnancy and breast-feeding: There isn't enough reliable information to know if Griffonia simplicifolia is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Surgery: 5-HTP, a chemical found in Griffonia simplicifolia, can affect a brain chemical called serotonin. Some drugs given during surgery can also affect serotonin. Taking Griffonia simplicifolia before surgery might cause too much serotonin in the brain. Stop taking Griffonia simplicifolia at least 2 weeks before surgery.
Interactions
Medications for depression (Antidepressant drugs) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP which increases a brain chemical called serotonin. Some medications for depression also increase serotonin. Taking Griffonia simplicifolia along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety.
Medications for depression (MAOIs) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP that increases a chemical in the brain called serotonin. Some medications used for depression also increase serotonin. Taking Griffonia simplicifolia with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.
Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
Major Interaction
Do not take this combination
Carbidopa (Lodosyn) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP which can affect the brain. Carbidopa can also affect the brain. Taking Griffonia simplicifolia along with carbidopa might increase the risk of serious side effects including rapid speech, anxiety, aggressiveness, and others.
Dextromethorphan (Robitussin DM, and others) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP that can affect a brain chemical called serotonin. Dextromethorphan can also affect serotonin. Taking Griffonia simplicifolia along with dextromethorphan might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety.
Meperidine (Demerol) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP that increases a chemical in the brain called serotonin. Meperidine can also increase serotonin in the brain. Taking Griffonia simplicifolia along with meperidine might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.
Pentazocine (Talwin) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP that increases a brain chemical called serotonin. Pentazocine also increases serotonin. Taking Griffonia simplicifolia along with pentazocine might increase serotonin too much. This might cause serious side effects including heart problems, shivering, and anxiety.
Sedative medications (CNS depressants) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking Griffonia simplicifolia with sedative medications might cause breathing problems and/or too much sleepiness.
Tramadol (Ultram) interacts with GRIFFONIA SIMPLICIFOLIA
Griffonia simplicifolia contains a chemical called 5-HTP that increases a brain chemical called serotonin. Tramadol can also increase serotonin. Taking Griffonia simplicifolia along with tramadol might cause too much serotonin in the brain and might result in side effects including confusion, shivering, stiff muscles, and others.
Moderate Interaction
Be cautious with this combination
Dosing
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.