Beta-hydroxy-beta-methylbutyrate, B-Hydroxy B-Methylbutyrate Monohydreate, Beta-Hydroxy-Beta-Methylbutyric Acid, Calcium B-Hydroxy B-Methylbutyrate Monohydrate, Calcium HMB, Hidroximetilbutirato, HMB, HMB de Calcium, Hydroxyméthylbutyrate, Hydroxymethyl Butyrate, Hydroxyméthyl Butyrate.<br/><br/>


Overview Information

Hydroxymethylbutyrate (HMB) is a chemical that is produced when the body breaks down leucine. Leucine is an amino acid, one of the building blocks of protein. People use HMB to make medicine.

HMB is used for increasing the benefits from weight training and exercise; and for treating diseases of the heart and blood vessels (cardiovascular disease), high cholesterol, and high blood pressure. In combination with the amino acids arginine and glutamine, HMB is also used for treating weight loss, weakness, and diarrhea in people with AIDS (AIDS-related wasting).

How does it work?

HMB might promote muscle growth. It seems to reduce the destructive breakdown of muscle in people with AIDS.


Uses & Effectiveness?

Possibly Effective for

  • Increasing body weight and muscle in people with acquired immunodeficiency syndrome (AIDS). Taking HMB by mouth, along with the amino acids arginine and glutamine, seems to increase body weight and lean body mass in people with AIDS when used for 8 weeks. This combination may also improve the way the immune system works in these people.
  • Age related muscle loss. Most research shows that taking HMB can slightly decrease the loss of muscle associated with aging.

Insufficient Evidence for

  • High cholesterol. Early research suggests that HMB can lower cholesterol.
  • High blood pressure. Early research suggests that HMB can lower blood pressure.
  • Muscle strength. Most research shows that HMB helps increase muscle a little in people who are just beginning to train but not in well-trained athletes.
  • Disease-related weight loss (cachexia).
  • Foot ulcers from diabetes.
  • Skin rash from radiation therapy for cancer.
  • Diseases of the heart and blood vessels (cardiovascular disease).
  • Other conditions.
More evidence is needed to rate HMB for these uses.

Side Effects

Side Effects & Safety

HMB is POSSIBLY SAFE for most people when taken by mouth, short-term. Doses of 3 grams per day or less for up to one year seem to be safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking HMB if you are pregnant or breast-feeding. Stay on the safe side and avoid use.



We currently have no information for HYDROXYMETHYLBUTYRATE Interactions.



The following doses have been studied in scientific research:


  • For treatment of weight loss, weakness, and diarrhea related to AIDS (AIDS-related wasting): 3 grams HMB in combination with 14 grams each of arginine and glutamine in two divided doses daily.

View References


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