By Steven Reinberg
Fluconazole (Diflucan) is a prescribed pill used to treat yeast infections. However, Canadian research now suggests its use greatly raises a pregnant woman's odd for miscarriage, as well as the odds that her baby will have a heart defect.
The findings could have implications for standard gynecological practice, according to one expert who reviewed the findings.
"Vaginal yeast infections can affect up to 75 percent of women during their lifetime and are more prevalent among pregnant women," said Dr. Mitchell Kramer, chair of obstetrics and gynecology at Northwell Health'sHuntington Hospital inHuntington, N.Y.
The new study echoes prior research "that revealed the adverse effect oral fluconazole has on pregnancy," he said. "Therefore, the use of oral fluconazole should be avoided in pregnancy."
He stressed that most pregnant women already avoid fluconazole.
"First-line treatment, especially in pregnant women, is a topical imidazole (Monistat) vaginal cream or suppository," Kramer said.
Fluconazole is still often used to fight yeast infections in women who aren't pregnant, however.
In the new study, a team led by Dr. Anick Berard, of University of Montreal in Quebec, examined data on nearly 442,000 pregnant women who took part in the Quebec Pregnancy Cohort between 1998 and 2015.
The researchers tracked the women's fluconazole use via prescription data from the Quebec Prescription Drug Insurance database.
The research couldn't prove cause-and-effect, but it did show associations between fluconazole use and adverse obstetric outcomes.
"Our study shows that taking any dose of oral fluconazole while pregnant may be associated with a higher chance of miscarriage," Berard said.
Specifically, women who took a lower dose of fluconazole (under 150 milligrams) had more than a doubling of their odds for miscarriage, compared to women who hadn't taken the drug while pregnant.
The increase in risk more than tripled for women who had taken fluconazole at a higher dose, Berard's team found.
In addition, taking higher doses (over 150 milligrams) of fluconazole during a woman's first trimester was linked to an 81 percent higher risk of having a baby with a heart defect, the Quebec team found.
Dr. Adi Davidov is interim chair of the department of obstetrics and gynecology at Staten Island University Hospital, in New York City. Reviewing the new study, he agreed that it "seriously questions the safety of oral fluconazole during pregnancy."
Davidov said that many pregnant women faced with a yeast infection do prefer a simple pill to a topical cream. But, "I suspect that following this article, obstetricians will stop prescribing fluconazole to pregnant patients," he said.
The report was published Feb. 19 in the CMAJ: Canadian Medical Association Journal.