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Allergy Medications

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In general, there is no cure for allergies, but there are several types of medications available -- both over-the-counter and prescription -- to help ease and treat annoying symptoms like congestion and runny nose. These allergy drugs include antihistamines, decongestants, combination drugs, corticosteroids, and others.

Allergy shots, which gradually increase your ability to tolerate allergens, are also available.

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Antihistamines have been used for years to treat allergy symptoms. They can be taken as pills, liquid, nasal spray, or eye drops. Over-the-counter (OTC) antihistamine eye drops can relieve red itchy eyes, while nasal sprays can be used to treat the symptoms of seasonal or year-round allergies.

Examples of antihistamines include:

How Do Antihistamines Work?

When you are exposed to an allergen -- for example ragweed pollen -- it triggers your immune system. People with allergies demonstrate an exaggerated immune response. Immune system cells known as "mast cells" release a substance called histamine, which attaches to receptors in blood vessels, causing them to enlarge. Histamine also binds to other receptors causing redness, swelling, itching, and changes in secretions. By blocking histamine and keeping it from binding to receptors, antihistamines prevent these symptoms.

What Are the Side Effects of Antihistamines?

Many older over-the-counter antihistamines may cause drowsiness. Newer, non-sedating second- and third-generation antihistamines are available over-the-counter or by prescription.


Decongestants relieve congestion and are often prescribed along with antihistamines for allergies. They can come in nasal spray, eye drop, liquid, or pill form.

Nasal spray and eye drop decongestants should be used for only a few days at a time, because long-term use can actually make symptoms worse. Pills and liquid decongestants may be taken longer safely.

Some examples of decongestants that are available over-the-counter and by prescription include:

  • Sudafed tablets or liquid, Neo-Synephrine and Afrin nasal sprays, and some Visine eye drops
  • Combination decongestant and antihistamine medications such as Allegra-D or Zyrtec-D
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