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    Amyloidosis

    Important
    It is possible that the main title of the report Amyloidosis is not the name you expected.

    Disorder Subdivisions

    • familial amyloidosis
    • primary amyloidosis
    • secondary amyloidosis
    • senile amyloidosis

    General Discussion

    Amyloidosis is a systemic disorder that is classified into several types. The different types of systemic amyloidosis are classified as primary, secondary or familial (hereditary). Primary amyloidosis (also called AL, or ‘light chain') is the most common type of systemic amyloidosis. AL results from an abnormality (dyscrasia) of plasma cells (a type of white blood cell) in the bone marrow and is closely related to multiple myeloma. Secondary (AA) amyloidosis is derived from the inflammatory protein serum amyloid A. AA occurs in association with chronic inflammatory disease such as the rheumatic diseases, familial Mediterranean fever, chronic inflammatory bowel disease, tuberculosis or empyema. Familial amyloidosis is a rare type of amyloidosis that is caused by an abnormal gene. There are several abnormal genes that can cause hereditary amyloidosis, but the most common type of hereditary amyloidosis is called ATTR and caused by mutations in the transthyretin (TTR) gene.

    Senile amyloidosis, in which the amyloid is derived from wild-type (normal) transthyretin, is a slowly progressive disease that affects the hearts of elderly men. Amyloid deposits may occasionally occur in isolation without evidence of a systemic disease; isolated bladder or tracheal amyloid are the most common such presentations.

    Resources

    International Myeloma Foundation
    12650 Riverside Drive
    Suite 206
    North Hollywood, CA 91607
    USA
    Tel: (818)487-7455
    Fax: (818)487-7454
    Tel: (800)452-2873
    Email: TheIMF@myeloma.org
    Internet: http://www.myeloma.org

    Multiple Myeloma Research Foundation
    383 Main Avenue
    5th Floor
    Norwalk, CT 06851
    USA
    Tel: (203)229-0464
    Fax: (203)229-0572
    Email: info@themmrf.org
    Internet: http://www.themmrf.org/

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Amyloidosis Support Groups
    232 Orchard Drive
    Wood Dale, IL 60191
    Tel: (847)350-7540
    Fax: (847)350-0577
    Tel: (866)404-7539
    Email: muriel@finkelsupply.com
    Internet: http://www.amyloidosissupport.com

    Amyloidosis Foundation
    7151 N. Main Street
    Suite 2
    Clarkston, MI 48346
    Tel: (248)922-9610
    Fax: (248)922-9620
    Tel: (877)269-5643
    Email: modonnell@amyloidosisresearchfoundation.org
    Internet: http://www.amyloidosis.org

    Who is Amy?
    3856 Winona Ct.
    Denver, CO 80212
    Tel: (303)917-9888
    Fax: (720)536-4661
    Email: becca.barry@whoisamy.org
    Internet: http://www.whoisamy.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 3/12/2013
    Copyright 1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991, 1992, 1995, 1996, 1997, 1998, 1999, 2001, 2002, 2003, 2006, 2007, 2010, 2013 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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