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Amyloidosis
Important
It is possible that the main title of the report Amyloidosisis not the name you expected.
Disorder Subdivisions
- Primary Amyloidosis
- Secondary Amyloidosis
- Hereditary Amyloidosis
- Localized Amyloidosis
General Discussion
Amyloidosis is a group of disorders caused by abnormal folding of proteins leading to fibril formation in one or more body organs, systems or soft tissues. These clumps of protein are called amyloid deposits and the accumulation of amyloid deposits causes the progressive malfunction and eventual failure of the affected organ. Normally, proteins are broken down at about the same rate as they are produced, but these unusually stable amyloid deposits are deposited more rapidly than they can be broken down. The accumulation may be localized in one organ or may be systemic such that several organs are affected.
The different types of systemic amyloidosis are sometimes classified as primary, secondary or hereditary. Primary amyloidosis (also called AL) is the most common type of systemic amyloidosis. It is caused by an abnormal plasma cell in the bone marrow and sometimes occurs with multiple myeloma. Secondary amyloidosis (also called AA) occurs in association with another disease such as rheumatoid arthritis, familial Mediterranean fever or other chronic infection or inflammatory disease. Hereditary amyloidosis is a rare type of amyloidosis that is caused by an abnormal gene. There are several abnormal genes that can cause hereditary amyloidosis, but the most common type of hereditary amyloidosis is called ATTR and caused by a mutations in the TTR gene.
Beta2-microglobulin amyloidosis (Aß2M) is a type of systemic amyloidosis that can occur in patients who have experienced long-term kidney dialysis to remove accumulated impurities or wastes in the blood by mechanical filtration.
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Resources
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains
NY
10605
Tel: (914)428-7100
Fax: (914)997-4763
800: (888)663-4637
Askus@marchofdimes.com
http://www.marchofdimes.com
NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
1 AMS Circle
Bethesda
MD
20892-3675
USA
Tel: (301)495-4484
Fax: (301)718-6366
800: (877)226-4267
TDD: (301)565-2966
NIAMSinfo@mail.nih.gov
http://www.niams.nih.gov/Health_Info
Association Fransaise Contre l'amylose
66, rue Saint Jacques
Immeuble le Pacin II
Marseille
Intl
13006
France
Tel: 04 42 94 90 86
Fax: 04 42 94 90 87
http://www.amylose.asso.fr
MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay
WI
54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
800: (877)336-5333
mums@netnet.net
http://www.netnet.net/mums/
Jack Miller Center for Peripheral Neuropathy
University of Chicago
5841 S. Maryland Ave, MC 2030
Chicago
IL
60637
Tel: (773)702-5800
Fax: (773)702-5577
information-millercenter@neurology.bsd.uchicago.edu
http://millercenter.uchicago.edu
Amyloidosis Support Groups, Inc
232 Orchard Drive
Wood Dale
IL
60191
Tel: (630)350-7539
Fax: (847)350-0577
800: (866)404-7539
muriel@amyloidosissupport.com
http://www.amyloidosissupport.com
Amyloidosis Australia, Inc.
17 Victoria Street
Ferntree Gully
Victoria
3156
Australia
Tel: (+61)03 9758 2172
Fax: (+61)03 9758 2172
ellen@amyloidosisaustralia.org
http://www.amyloidosisaustralia.org
Amyloidosis Foundation
7151 N. Main St.
Suite 208
Clarkston
MI
48346
Tel: (248)922-9610
Fax: (248)922-9620
800: (877)269-5643
modonnell@amyloidosisresearchfoundation.org
http://www.amyloidosis.org and http://www.amyloidosisresearchfoundation.org
UCSF Hemophilia Treatment Center
400 Parnassus Ave.
First Floor
San Francisco
CA
94143
Tel: (415)353-2986
Fax: (415)353-2600
http://www.ucsfhealth.org/adult/medical_services/blood/hemophilia/index.html
Cancer.Net
American Society of Clinical Oncology
2318 Mill Road
Suite 800
Alexandria
VA
22314
Tel: (571)483-1780
Fax: (571)366-9537
800: (888)651-3038
contactus@cancer.net
http://www.cancer.net/patient
Kidney & Urology Foundation of America, Inc.
152 Madison Ave.
Suite 201
New York
NY
10016
Tel: (212)629-9770
Fax: (212)629-5652
800: (800)633-6628
info@kidneyurology.org
http://www.kidneyurology.org
For a Complete Report:
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 4/29/2008
Copyright 1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991, 1992, 1995, 1996, 1997, 1998, 1999, 2001, 2002, 2003, 2006, 2007 National Organization for Rare Disorders, Inc.
WebMD Medical Reference from the National Organization of Rare Disorders
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