Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier
WebMD

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine
WebMD

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion
    WebMD

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community
    WebMD

    Community

    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size
A
A
A

Analgesic Nephropathy

An analgesic (AN-ul-JEE-zik) is any medicine intended to kill pain. Over-the-counter analgesics (medicines bought without a prescription) include aspirin, acetaminophen, ibuprofen, naproxen sodium, and others. These drugs present no danger for most people when taken in the recommended dosage. But some conditions make taking even these common painkillers dangerous for the kidneys. Also, taking one or a combination of these drugs regularly over a long period of time may increase the risk for kidney problems. Most drugs that can cause kidney damage are the ones that are excreted only through the kidneys.

Case reports have attributed incidents of acute kidney failure to the use of painkillers, including aspirin, ibuprofen, and naproxen. The patients in these reports had risk factors such as systemic lupus erythematosus, advanced age, chronic renal conditions, or a recent binge of alcohol consumption. These cases involved a single dose in some instances and never more than 10 days of analgesic use. Acute kidney failure requires emergency dialysis to clean the blood. But normal kidney function often returns after the emergency is over.

Recommended Related to

Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) causes a lot of fluid-filled sacs, called cysts, to grow in your kidneys. The cysts keep your kidneys from working like they should. That can cause health problems like high blood pressure, infections, and kidney stones. It can also cause kidney failure, although that doesn't happen to everyone. You can have ADPKD and not know it for many years. It’s often called “adult PKD,” because the symptoms don't usually appear until people reach ages 30...

Read the Autosomal Dominant Polycystic Kidney Disease article > >

A different kind of problem can result from taking painkillers every day for several years. Analgesic nephropathy is a chronic kidney disease that gradually leads to end-stage renal disease and the permanent need for dialysis or a kidney transplant to restore renal function.

The painkillers that combine two or more analgesics (for example, aspirin and acetaminophen together) with caffeine or codeine are most likely to damage the kidneys. These mixtures are often sold as powders. Single analgesics (e.g., aspirin alone) have not been found to cause kidney damage.

Patients with conditions that put them at risk for acute kidney failure should check with their doctors before taking any medicine. People who take painkillers on a regular basis should check with their doctors to make sure they are not hurting their kidneys. The doctor may be able to recommend a safer alternative.

For More Information

Contact the following organizations:

American Kidney Fund
11921 Rockville Pike, Suite 300
Rockville, MD 20852
(800) 638-8299
Home page: http://www.kidneyfund.org

National Kidney Foundation
30 East 33rd Street
New York, NY 10016
(800) 622-9010
Home page:http://www.kidney.org

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

disciplining a boy
Types, symptoms, causes.
fruit drinks
Eat these to think better.
Balding man in mirror
Treatments & solutions.
No gym workout
Moves to help control blood sugar.
Remember your finger
Are you getting more forgetful?
acupuncture needle on shoulder
10 tips to look and feel good.
Close up of eye
12 reasons you're distracted.
birth control pills
Which kind is right for you?
embarrassed woman
Do you feel guilty after eating?
woman biting a big ice cube
Habits that wreck your teeth.
pacemaker next to xray
Treatment options.
Pink badge on woman chest to support breat cancer
Myths and facts.

Pollen counts, treatment tips, and more.

It's nothing to sneeze at.

Loading ...

Sending your email...

This feature is temporarily unavailable. Please try again later.

Thanks!

Now check your email account on your mobile phone to download your new app.

Women's Health Newsletter

Find out what women really need.