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Sickle Cell Disease

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Cause

Sickle cell disease is an inherited disorder. More specifically, sickle cell disease is an autosomal recessive disease. This means that to have the disease, you must inherit a gene for the disease from both parents.

  • Normally, a person inherits two genes that tell the body to produce normal hemoglobin A. One gene comes from each parent.
  • People who inherit one defective hemoglobin S gene and one normal hemoglobin A gene have sickle cell trait. These people don't have symptoms of sickle cell disease, nor do their bodies make sickled blood cells. However, they can pass the defective hemoglobin S gene to their children.
  • Sickle cell disease occurs when a person inherits one defective hemoglobin S gene from each parent.
  • Similar sickle cell disorders occur when a person inherits a hemoglobin S gene from one parent and another type of defective hemoglobin gene from the other parent. Sickle cell disease is a sickle cell disorder.

For more information, see autosomal recessive disease and an illustration of this risk.

WebMD Medical Reference from Healthwise

Last Updated: January 19, 2007
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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