Painful events (sickle cell crises) in the hands or
feet, belly, back, or chest are the most common symptom of
sickle cell disease. This pain may last from hours to
days. Most people with sickle cell disease also get
When a child is born with
sickle cell disease, it isn't possible to predict which symptoms will appear,
when they will start, or how bad they will be.
Symptoms related to chronic anemia
Most people who have sickle cell disease
have at least mild symptoms of chronic anemia, which may include:
- Tiredness (fatigue).
- Pale appearance.
- Yellowing of the skin and the whites of the eyes
- Shortness of breath, especially when they are active.
Severe anemia may raise the chance of a person with sickle
cell disease getting high blood pressure in the lungs (pulmonary hypertension). This can be deadly.
Symptoms caused by sickle cell crisis
Painful sickle cell crisis symptoms are caused by blocked blood vessels in bones, organs, and other
tissues. This can cause extreme pain for hours or days. These
painful events can occur rarely to often. Sometimes
home treatment can help the pain. And sometimes a hospital stay is
Infants and young children may have episodes of
extreme pain in the hands, the feet, or both (hand-foot syndrome).