Skip to content


Font Size

Topic Overview

Uremia (uremic syndrome) is a serious complication of chronic kidney disease and acute kidney injury (also known as acute renal failure). It occurs when urea and other waste products build up in the body because the kidneys are unable to eliminate them. These substances can become poisonous (toxic) to the body if they reach high levels.

Prolonged or severe fluid buildup (edema) may make the uremic syndrome worse.

Uremic syndrome may affect any part of the body and can cause:

  • Nausea, vomiting, loss of appetite, and weight loss.
  • Changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma.
  • Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury.
  • Heart problems, such as an irregular heartbeat, inflammation in the sac that surrounds the heart (pericarditis), and increased pressure on the heart.
  • Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion).

Kidney dialysis is usually needed to relieve the symptoms of uremic syndrome until normal kidney function can be restored.


WebMD Medical Reference from Healthwise

Last Updated: November 14, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Next Article:

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

disciplining a boy
Types, symptoms, causes.
Remember your finger
Are You Getting More Forgetful?
fruit drinks
Eat these to think better.
No gym workout
Moves to help control blood sugar.
acupuncture needle on shoulder
10 tips to look and feel good.
Close up of eye
12 reasons you're distracted.
birth control pills
Which kind is right for you?
embarrassed woman
Do you feel guilty after eating?
Epinephrine Injection using Auto-Injector Syringe
Life-threatening triggers.
woman biting a big ice cube
Habits that wreck your teeth.
pacemaker next to xray
Treatment options.
caregiver with parent
10 tips for daily life.

Women's Health Newsletter

Find out what women really need.