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Understanding Anaphylaxis -- Diagnosis & Treatment

How Is Anaphylaxis Diagnosed?

Anaphylaxis is diagnosed on the basis of its signs and symptoms and history of exposure to an allergen.

It is difficult to gauge an individual's potential for a severe allergic response before it occurs. However, those with a history of allergic reactions -- mild, moderate, or severe -- may be at greater risk of having a severe reaction in the future.

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Tests that are commonly used to assess allergic responses include skin-prick tests and radioallergosorbent (RAST) blood tests. Skin-prick tests involve putting small amounts of suspected allergens under the skin on the arm or back and watching for signs of allergic reaction.

What Are the Treatments for Anaphylaxis?

Epinephrine by injection is the only effective immediate treatment for anaphylaxis. It rapidly reverses the uncomfortable flushing and itching that accompanies most anaphylactic reactions. Epinephrine can also reverse the life-threatening symptoms of anaphylactic shock, if given in time. If you are allergic to insect stings or any of the foods that are common causes of anaphylaxis, or if you ever have had an anaphylactic reaction, you should carry an epinephrine injection kit (Epi-Pen is one common brand name) at all times and know how to use it. If you're at risk, make sure your family members, friends, and colleagues know the signs of anaphylaxis and how to give you an injection, if needed.

If someone appears to be suffering from anaphylaxis, call for emergency help, even if the person has been given an epinephrine injection. Anyone who has an anaphylactic reaction should be checked by medical personnel. After getting epinephrine, steroid drugs (such as prednisoneor methylprednisolone) and antihistamines (given after epinephrine) can also help to calm hives and itching and prevent the return of acute symptoms.

If a victim of anaphylaxis stops breathing, perform cardiopulmonary resuscitation (CPR) immediately. Continue CPR until the person begins breathing again or emergency medical personnel take over.

Certain medicines, such as beta-blockers (often given for high blood pressure) and angiotensin-converting enzyme (ACE) inhibitors (often given for heart disease), may hinder the successful treatment of an anaphylactic reaction. If you ever have suffered a severe allergic reaction and are taking either of these drugs, ask your doctor whether your medication should be changed.

WebMD Medical Reference

Reviewed by Jonathan L Gelfand, MD on October 25, 2010

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