Selected classes of chemotherapy, including the vinca alkaloids, vincristine, and vinblastine, can cause direct neurotoxicity. Additionally, drugs such as thalidomide and lenalidomide are associated with peripheral neuropathies that can affect the face and jaw. Deep-seated, throbbing mandibular pain can occur. Because this symptom is also consistent with acute dental pulpal disease, it is important that a thorough history and oral physical examination be performed when oral pain is present; radiographs...
These tumors are often slow-growing. As many as 90% are benign (not cancerous).
Most meningiomas occur in the brain. But they can also grow on parts of the spinal cord.
Often, meningiomas cause no symptoms and require no immediate treatment. But the growth of benign meningiomas can cause serious problems. In some cases, such growth can be fatal.
Meningiomas are the most common type of tumor that originates in the central nervous system. They occur more often in women than in men.
Some meningiomas are classified as atypical. These are not considered either benign or malignant (cancerous). But they may become malignant.
A small number of meningiomas are cancerous. They tend to grow quickly. They also can spread to other parts of the brain and beyond, often to the lungs.
Causes and Risk Factors of Meningioma
The causes of meningioma are not well understood. However, there are two known risk factors.
Exposure to radiation
Neurofibromatosis type 2, a genetic disorder
Previous injury may also be a risk factor, but a recent study failed to confirm this. Meningiomas have been found in places where skull fractures have occurred. They've also been found in places where the surrounding membrane has been scarred.
Some research suggests a link between meningiomas and the hormone progesterone.
Middle-aged women are more than twice as likely as men to develop a meningioma. Most meningiomas occur between the ages of 30 and 70. They are very rare in children.
Because most meningiomas grow very slowly, symptoms often develop gradually, if they develop at all. The most common symptoms include:
Weakness in arms or legs
Diagnosis of Meningiomas
Meningiomas are rarely diagnosed before they begin to cause symptoms.
If symptoms indicate the possibility of a tumor, a doctor may order a brain scan: an MRI and/or a CT scan. These will allow the doctor to locate the meningioma and determine its size.
A biopsy may sometimes be performed. A surgeon removes part or all of the tumor to determine whether it is benign or malignant.
If the tumor is not causing any symptoms, observation is often recommended. Regular brain scans will be performed to determine if the tumor is growing.
If the tumor's growth threatens to cause problems or if symptoms begin to develop, surgery may be necessary.
If surgery is required, a craniotomy will typically be performed. The procedure involves removing a piece of bone from the skull. This gives the surgeon access to the affected portion of the brain.
The surgeon then removes the tumor -- or as much of it as possible. The bone that was removed at the start of the procedure is then replaced.
The location of the meningioma will determine how accessible it is to the surgeon. If it can't be reached via surgery, radiation therapy may be used. Radiation can shrink the tumor or help prevent it from growing any larger.
Radiation can also be used to kill cancer cells if the tumor is malignant. It may also be used on the parts of a tumor the surgeon was unable to remove.