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Hormone Therapy for Breast Cancer

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Ovarian Ablation for Breast Cancer

Some women with breast cancer may benefit from ovarian ablation, if they have not yet gone through menopause and their cancer is ER-positive. Ovarian ablation stops the ovaries from making estrogen. This can be done by:

  • Aiming radiation at the ovaries
  • Surgically removing the ovaries
  • Giving the woman a drug called luteinizing hormone-releasing hormone (LHRH) agonist

Ovarian ablation can also be done in combination with tamoxifen. Studies have shown that giving women an LHRH agonist alone or with tamoxifen has been at least as effective as the chemotherapy combination used in hormone-sensitive, early breast cancer and in metastatic breast cancer in premenopausal women.

Before you begin breast cancer treatment, print out Questions to Ask at your first appointment.

Recognizing a Breast Cancer Emergency

Call your doctor if you have:

  • A temperature greater than 100.4 F. If you have a fever and chills, tell your doctor immediately. If you can't reach your regular doctor, go to the emergency room.
  • New sores or patches in your mouth, a swollen tongue, or bleeding gums
  • A dry, burning, scratchy, or "swollen" throat
  • A cough that is new or doesn't go away and has mucus
  • Changes in bladder function, including increased frequency or urgency to go, burning during urination, or blood in your urine
  • Heartburn, nausea, vomiting, constipation, or diarrhea that lasts longer than 2 or 3 days, or blood in your stools

WebMD Medical Reference

Reviewed by Angela Jain on April 15, 2014
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