In breast cancer, a sentinel node biopsy pinpoints the first few lymph nodes into which a tumor drains (called the "sentinel" node). This helps doctors remove only those nodes of the lymphatic system most likely to contain cancer cells. The sentinel nodes are the first place that cancer is likely to spread.
In breast cancer, the sentinel node is usually located in the axillary nodes, under the arm. In a small percentage of cases, the sentinel node is found somewhere else in the lymphatic system of the breast. If the sentinel node is positive, there may be other positive lymph nodes upstream. If it is negative, it is highly likely that all of the upstream nodes are negative.
The FDA has ruled that the cancer drug Avastin is no longer approved for treating advanced breast cancer -- but can still be used for other cancers.
In a news release, the FDA stated that Avastin "has not been shown to be safe and effective" for treating breast cancer, but that Avastin would stay on the market as an FDA-approved treatment for certain types of colon, lung, kidney, and brain cancer.
The FDA states that Avastin's risks include severe high blood pressure; bleeding;...
To locate the sentinel nodes, a labeling substance, either a radioactive tracer, blue dye, or both, is injected into the area around the tumor before a mastectomy or lumpectomy is performed. The tracer travels the same path to the lymph nodes that the cancer cells would take, making it possible for the surgeon to determine the one or two nodes most likely to test positive for cancer by either visualizing the color or using a handheld Geiger counter. This method varies in how it is performed among hospitals.
What Are the Advantages of a Sentinel Node Biopsy?
Research suggests that the sentinel node biopsy procedure can be useful in determining which lymph nodes to remove, without the risk of complications associated with surgically removing all potentially cancerous nodes.
When a lumpectomy or mastectomy is performed, only a few lymph nodes are removed for laboratory analysis using the sentinel node biopsy technique. In traditional lumpectomy or mastectomy procedures, a greater number of the axillary nodes are removed, which may lead to complications after surgery, such as lymphedema, or swelling of the arm or hand.