Treatment Options for Spinal Cord Tumors
Treatment of spinal cord tumors may include the following:Surgery to remove the tumor.Radiation therapy.Chemotherapy, if the tumor has spread from the spinal cord to the leptomeninges (the two innermost membranes covering the brain and spinal cord).A clinical trial of a new treatment.
Adrenocorticotropic Hormone-Producing Pituitary Tumors Treatment
Standard Treatment Options for Adrenocorticotropic Hormone (ACTH)-Producing Pituitary TumorsStandard treatment options for ACTH-producing pituitary tumors include the following:Surgery (usually a transsphenoidal approach).[1,2,3]Surgery plus radiation therapy.[1,2,4]Radiation therapy.[1,2,4]Steroidogenesis inhibitors, including mitotane, metyrapone, ketoconazole, and aminoglutethimide.[1,2,5]For patients with corticotroph adenomas, transsphenoidal microsurgery is the treatment of choice.[1,2] Remission rates reported in most series are approximately 70% to 90%. In a series of 216 patients, who were operated on using a transsphenoidal approach, 75% experienced long-term remission, 21% experienced persistence of Cushing disease, and 9% had recurrence after the initial correction of the hypercortisolism. The average time interval for reoperation was 3.8 years. Seventy-nine percent of the tumors were microadenomas, and 18% were macroadenomas; 86% of the cases with microadenoma had
Stages of Childhood Brain Stem Glioma
After the childhood brain stem glioma has been removed,tests are done to find out if there is tumor remaining. The extent or spread of cancer is usually described as stages. For childhood brain stem glioma,the tumors are described by type: Diffuse intrinsic pontine glioma is a tumor that has spread widely throughout the brain stem. Focal or low-grade glioma is a tumor that is localized to ...
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Classification of Central Nervous System Tumors
The classification of childhood central nervous system (CNS) tumors is based on histology and location. Tumors are classically categorized as infratentorial, supratentorial, parasellar, or spinal. Immunohistochemical analysis, cytogenetic and molecular genetic findings, and measures of mitotic activity are increasingly used in tumor diagnosis and classification, and will likely alter classification and nomenclature in the future.Primary CNS spinal cord tumors comprise approximately 1% to 2% of all childhood CNS tumors. The classification of spinal cord tumors is based on histopathologic characteristics of the tumor and does not differ from that of primary brain tumors.[2,3,4]Infratentorial (posterior fossa) tumors include the following:Cerebellar astrocytomas (most commonly pilocytic, but also fibrillary and less frequently, high-grade).Medulloblastomas (classic, desmoplastic/nodular, extensive nodularity, anaplastic, or large cell) and variants.Ependymomas (cellular, papillary,
Changes to This Summary (01 / 30 / 2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Treatment of Recurrent Childhood EpendymomaAdded Bouffet et al. as reference 8.This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Childhood Brain Stem Glioma Treatment
Treatment Option Overview
Many of the improvements in survival in childhood cancer have been made as a result of clinical trials that have attempted to improve on the best available,accepted therapy. Clinical trials in pediatrics are designed to compare new therapy with therapy that is currently accepted as standard. This comparison may be done in a randomized study of two treatment arms or by evaluating a single new ...
Growth Hormone-Producing Pituitary Tumors Treatment
Standard Treatment Options for Growth Hormone (GH)-Producing Pituitary TumorsStandard treatment options for GH-producing pituitary tumors include the following:Surgery (usually a transsphenoidal approach).Dopamine analogues, such as bromocriptine.Somatostatin analogues, such as octreotide. The GH-receptor antagonist, pegvisomant.[1,2]Surgery and postoperative radiation therapy.Treatment for patients with acromegaly includes surgical, radiation, and medical therapies. Treatment will depend on the size and extent of the tumor and the need for rapid cessation of hormone function that results in serious clinical sequelae (i.e., hypertension and cardiomyopathy). Microadenomectomy or macroadenoma decompression is approached transsphenoidally in most patients. Increasingly, endoscopic surgery is used to allow the entire surgical field to be viewed and to allow tumor tissue that would otherwise be inaccessible with rigid instruments to be safely resected. Complete return of GH