I have been on Dexedrine Spansule since 1997, fourteen yrs, it is the best stimulant med I have ever taken for ADHD. I was given the diagnosis during 1994 at age 45. The 1st 3 yrs I took Ritalin 20mg x 3 tabs per day. Methylphenidate changed my life for the positive, but, the necessary timing, to take the tabs daily, became a hassle, and, switching to Dexedrine Spansule 15mg in the AM hours, and, having the Dexedrine Sulfate 5 mg instant release, for after 5 PM dosing, was the perfect combination. Unfortunately, GlaxoSmithKline removed the Dexedrine 5 mg tabs off of the USA market in 2009, thus, I now take Adderall 12.5 mg when the early AM dose of pure Dexedrine Spansule wears off. The Dexedrine I/R 5 mg I liked better, for 3 to 4 hrs of focusing ability, than, the current, Adderall or generic Adderall instant release. My deepest regret is not getting the ADHD diagnosis until age 45, because I had crystal clear symptoms since at least age 7, thus, I lost 38 yrs of my life, including blotched interpersonal relationships, job firings, job mismatches, 7 yrs to complete a 4 year Bachelors Degree, etc. Thus I am damaged merchandise, due to resentments. Individual Psychotherapy, Group Psychotherapy, one dozen books written by M.D's & Ph.D's have helped, along, with attendance to some national ADDA conventions. Drug trials with any other form of Ritalin/Methylphenidate, tri-cycle anti-depressants, Wellbutrin, SSRI's, SNRI's, have not measured up to brand name Dexedrine. I also prefer the brand name Dexedrine Sulfate, or Dexedrine Spansule, or Adderall instant release, due to the FDA's non regulation of the bioavailability (breakdown of the med in the body) with generic firms...as regulation of the bioequivalence, is not enought for me, just my 2 cents worth. The price of the generics vs. the brand name "borders highway robbery", in my humble opinion. Read More Read Less