Splenic sequestration happens when a lot of sickled red
blood cells become trapped in the
spleen. The spleen can enlarge, get damaged, and not work as it should. When
the spleen doesn't work well, a person is more likely to have serious,
life-threatening infections with certain types of bacteria.
An FDA advisory committee recently recommended that the FDA set certain limits on acetaminophen, a drug that is used in many prescription and nonprescription medicines to relieve pain and reduce fever.
Those limits could include taking off the market some prescription drugs, such as the painkillers Percocet and Vicodin, which combine acetaminophen with other active ingredients.
The reason for the proposed limits is the risk of liver damage from taking too much acetaminophen.
If splenic sequestration happens suddenly, it can be a life-threatening emergency.
Who is affected by it?
This condition is more common in infants and young children who have sickle cell disease. It may follow a respiratory infection.
In older children
and adults, the spleen often does not work because of years of damage from sickled
What are the symptoms?
Splenic sequestration causes sudden and severe
anemia, with symptoms of sudden weakness, pale lips,
rapid breathing, excessive thirst, belly pain, and rapid heartbeat.
If you have a baby or young child who has sickle cell disease, you will check your child's spleen to see if it's larger than normal. Your child's doctor can show you how to check for it. A suddenly enlarged spleen requires emergency medical
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
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WebMD Medical Reference from Healthwise
March 12, 2014
This information is not intended to replace the advice of a doctor.
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