Treatment for HER2-Negative Advanced Breast Cancer

When you have HER2-negative advanced (metastatic) breast cancer, treatment usually focuses on managing your disease, not curing the cancer. The goal is to help you live longer and have a better quality of life.

This type of cancer is most often treated with systemic therapy. These drugs go into your bloodstream to send treatment to cells and organs throughout your body. Systemic therapies include:

  • Hormonal treatments
  • Chemotherapy
  • Targeted therapy
  • Immunotherapy

Some women also have surgery or radiation to prevent or treat symptoms.

Hormonal Therapies

Hormonal therapy is often the first treatment doctors use for women with HER2-negative advanced breast cancer that's "hormone receptor positive."

Some 50%-70% of breast cancers are hormone receptor positive. That means your hormones, like estrogen or progesterone, help the cancer grow.

Hormonal or endocrine therapies help to block this process. Some drugs lower your levels of estrogen. Others stop estrogen from connecting to cancer cells so they can’t multiply.

Hormonal therapies have a lower risk of serious side effects than chemotherapy. So you may have a better quality of life during treatment. You can take them as pills or in a shot.

Hormonal therapies include:

  • Aromatase inhibitors (AIs) like anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara)
  • Fulvestrant (Faslodex)
  • Tamoxifen (Nolvadex, Soltamox)
  • Toremifene (Fareston)
  • Drugs that stop your body from making estrogen, like goserelin (Zoladex) and leuprolide (Lupron)

Some women also have surgery to remove their ovaries.

Chemotherapy

Chemotherapy or "chemo" is medicine that kills cancer cells. You can take it as pills or get them through an IV.

Many different chemotherapy drugs are used, either alone or in combination, to treat HER2-negative breast cancer. Your doctor will prescribe a chemo drug based on:

  • Your past treatments
  • Your preferences
  • Any other conditions you have
  • Your risk of side effects

Categories of chemo drugs called taxanes and anthracyclines are often used to treat this cancer. But there’s no evidence that any single drug works better than another one.

Often, you get chemo drugs in cycles of 2 to 3 weeks. Between cycles, you have a rest period so your body can recover from the drug's effects.

Continued

Targeted Therapies

Targeted therapies block certain proteins or molecules that drive the growth and spread of cancer cells. Those molecules are the "targets" of the drugs.

There's a lot of research into targeted therapies for cancer. These drugs are also called precision medicine. That's because your doctor prescribes a certain drug based on your genes or the proteins associated with your specific cancer.

Targeted therapies for HER2-negative advanced breast cancer include:

PARP inhibitors like olaparib (Lynparza) and talazoparib (Talzenna). These drugs stop a protein known as poly-ADP ribose polymerase (PARP) from repairing cancer cells, so the cells die. They're given to women who have a mutation in the BRCA gene and HER2-negative breast cancer.

Everolimus (Afinitor). This drug blocks a protein called mTOR, which helps cancer cells grow and multiply. It may also stop tumors from making blood vessels that fuel their growth.

CDK4/6 inhibitors like abemaciclib (Verzenio), palpociclib (Ibrance), and ribociclib (Kisqali). These block proteins called cyclin-dependent kinases and slow the cancer’s growth.

Alpelisib (Piqray). This drug blocks the protein PI3K in cancer cells, so they stop growing. Up to 40% of women with breast cancer have a mutation in the PI3KCA gene.

Antibody-drug conjugates (ADCs). This type includes drugs like sacituzumab govitecan-hziy (Trodelvy). It targets a protein called Trop-2 to bring chemo drugs directly into your cancer cells.  

Immunotherapy

Immunotherapy uses the power of your immune system to fight cancer. Drugs called immune checkpoint inhibitors can be used to treat certain types of advanced breast cancer.

Immune "checkpoints" are proteins. They help your immune system tell the difference between healthy cells and dangerous ones. But cancer cells sometimes use them to hide from your immune system.

Atezolizumab (Tecentriq) stops the checkpoint protein PD-1 from attaching to another protein, PD-L1, that sits on the surface of T cells. T cells are immune cells that circulate through your body to fight disease. But when PD-1 binds with PD-L1, the T cells can’t do their job. Atezolizumab stops these proteins from linking up. This lets your T cells find and kill your cancer.

It only works on breast cancer that is PD-L1-positive.

Continued

Palliative Care

Once you’re diagnosed with HER2-negative advanced breast cancer, you may also consider starting palliative care. Palliative therapies treat pain, anxiety, and other issues that can come along with cancer.

You can get palliative care from:

  • Your cancer doctor
  • Nurses
  • Therapists
  • Social workers
  • Psychologists
  • Dietitians
  • Your pastor, if you choose

Clinical Trials

You may want to enroll in a clinical trial to try a drug that isn’t yet approved for advanced breast cancer. Your doctor can tell you more about clinical trials and whether you qualify for one.

WebMD Medical Reference Reviewed by Laura J. Martin, MD on May 27, 2020

Sources

SOURCES:

American Society of Clinical Oncology: “Treatment of Advanced HER2-Negative Breast Cancer,” “Breast Cancer: Introduction,” “Breast Cancer - Metastatic: Treatment Options,” “Breast Cancer - Metastatic: About Clinical Trials,” “Breast Cancer - Metastatic: Palliative Care.”

American Cancer Society: “Treatment of Breast Cancer by Stage,” “Chemotherapy for Breast Cancer,” “Hormone Therapy for Breast Cancer.”

National Cancer Institute: “Breast Cancer Treatment (PDQ®)–Patient Version,” “Coping With Advanced Cancer.”

National Comprehensive Cancer Network: “NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Breast Cancer, Version 3.2017 – November 10, 2017.”

© 2020 WebMD, LLC. All rights reserved.

Pagination