This medication is used to treat migraines. Zavegepant may work by blocking the effects of a certain natural substance in the brain that causes migraines (calcitonin gene-related peptide - CGRP).
Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using zavegepant and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This product is for use in the nose only. Remove the zavegepant spray from the package only when you are ready to use it. Do not test or prime the spray before use. Doing so will make you lose the dose.
Use this medication at the first sign of a migraine as directed by your doctor, usually 1 spray into one nostril. Do not use more than one dose in a 24-hour period. Avoid spraying into your eyes. Gently blow your nose before using this medication. Keeping your head upright, close one nostril by pressing with your index finger on one side of your nose. Place the nozzle of the spray device into the other nostril and breathe in gently as you press the plunger. Keep your head upright, remove the nozzle from your nose, and gently breathe in through your nose and out through your mouth for 10 to 20 seconds. Do not use more than 8 doses of this medication per month.
Avoid using decongestant nasal sprays at the same time as this medication. If needed, use decongestant nasal sprays at least 1 hour after using zavegepant.
If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse (medication overuse headache). Do not use medications more often or for longer than directed. Tell your doctor if you need to use this medication more often, or if the medication is not working as well, or if your headaches get worse.
Nausea, unusual taste or loss of taste, or irritation of the nose may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using zavegepant, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
See also How to Use section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Other medications can affect the removal of zavegepant from your body, which may affect how zavegepant works. An example is rifampin.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others.
Certain foods, beverages, or food additives (such as red wine, cheese, chocolate, monosodium glutamate) as well as lifestyle patterns such as irregular eating/sleeping habits or stress may bring on a migraine. Avoiding these "triggers" may help lessen migraine attacks. Consult your doctor for more details.
Not applicable.
Store at room temperature. Do not freeze. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.