User Reviews for Hysingla ER oral

After almost 7 years of Norco 10 3-4x daily- with a 3 month gap with Nucynta- I really wanted to give Hysingla a try if for no other reason than to stop beating up my liver with acetaminophen. Just a quick note that the Nucynta made me noticeably moody which was unfortunate because it worked very well. As for the Hysingla in question, I started on 40s for the past two months. The good news is that it has been a very "even" medication through the 21-22 hrs (not 24) that it lasts. For reference, let's say it pretty much keeps my pain level at a high 5. The bad news is the same effective dosage of Norco, (4) 10s, AVERAGES a pain level of mid-4 and has an initial 3 level even though unlike the Hysingla, it trails off steeply the last hour or so. Bottom line is I'm not sure if the one-a-day convenience, losing all that damn acetaminophen, and having a very consistent level of pain reduction is worth enduring less average relief (level 5.5 vs 4.5 as noted above). The difference is just enough to always feel some discomfort. I have no explanation for why 40mg over 24 hours in one pill isn't the same as 40mg over 24 hours in (4) 10mg pills but that's just the way it is for me. My Dr. Is willing to move the dosage up but the next step in Hysingla is 60mg. It doesn't sound like a lot but it's 50% more in reality. That's a huge jump and I'm not sure I'm comfortable with that. I'm leaning towards giving it a shot but I'd really like to hear from people like you with similar experiences. Read More Read Less

i have been trying to get started but cant get my saving card activated. any ideas

My first month in pain management I was prescribed 20 or 30mg hysingla in addition to 3 7.5 hydrocodone a day. The only relief I feel is after I take a 7.5mg hydrocodone and the relief is only for about an hour and a half. I told my Dr the situation and she moved the dose of hysingla to a 40mg and left the hydrocodone the same. 0% change in results. The next month I told her the same thing, that the only relief I got was when taking a 7.5 hydrocodone for about an hour and a half. I was then given 60mg hysingla and one of three of the 7.5 hydrocodone taken away from my daily routine. Needless to say I'm not making it through my 12hr work day anymore. I'm in fear of losing my job from constantly having to slow down and stretch or completely lay out of going because I can't take the pain. I don't know what to do. I don't want to end up needing something that doesn't even work for me. I don't want to keep getting the hysingla dose raised until 120mg and end up addicted to something that doesn't help my pain. I just don't understand. I am of the opinion that this medication has been made so indestructible and tamper proof that my digestive system can't break it down. Any advice? Change DR's? I'm out of ideas.Read More Read Less

I'm am desperately hoping to change my review. I'm on day 3 (30 mg) and haven't noticed it working AT ALL. I've been having to take my regular narcotic, without being able to decrease my "before Hysingla dosage" same with my nerve blocking medication. I don't want to be on ANY pain medication at all, but am physically unable to care for myself without it. I don't want to have to take a more powerful narcotic, and I don't want to take 10 hydrocodone a day (which is my current dosage). I have refused all upgrades to Oxy, Fentynal or Narco. I don't want to live like this. I want to still have a liver at 40, I don't want to be on ANY pain management meds at all... but i have no choice if I want to even be able to shower or feed myself without assistance. I'm desperate that Hysingla will start to work soon, I hope without the "high" other users have mentioned (although my pain is severe and chronic enough I've NEVER experienced a high from any opioid or narcotic). I am really hoping that it will start to work soon. My only option after this is something more "high grade". Read More Read Less

I feel absolutely no relief with this medication (40 mg) compared to 37.5 fentynal patch and 10/325 hydrocodone. In fact, on this medication I got withdrawals and super bad headaches. Could it be that my body does not dissolve the medicine properly? I was so excited about a once a day medication. Now just bummed.

Prescribed 80 mg. four months ago. No appetite due to nausea - have lost 5 lbs. and can't afford to lose any. Severe drowsiness during the afternoon, yet there are instances where I am unable to stay asleep through the night. Must add 20 mg. Norco for breakthrough pain at least once a day.

After many years taking several norco 10/325 per day along with other breakthrough medications, this once per day 20mg hysingla er is amazing. While my dose may need to be bumped up to the 30 mg to avoid a one time per day Norco, this is the first pain reliever that provides me with near 24 hour relief.

Easy to use so I don't have to keep time, but not as effective as manual dosage. Also, I coincidentally gained 9 pounds in a month AFTER returning to the gym and cutting back on food--WEIRD. No nausea, no drowsiness, constipation is also relieved somewhat, but breakthrough pain is annoying. It seems cyclical. Not sure what to do at this point, just trying to bear it until I go back to dr. Wouldn't recommend.

I have COPD,kidney disease, diabetes and a hiatal hernia.I do not believe the doctor took my medical history into account. I cannot breathe,because Hysingla works on my respiratory system making it harder to breathe, sleep,cough and causes a drop in blood pressure and respiration.I have been sleeping in my recliner so I can breathe. The side effects out way the effectiveness. This medication scares me, or should I be more scared of the doctor that does not take time to read my medical history; because I am certain this medication was approved by they FDA,November, 2014! I am not a guinea pig!!!Read More Read Less

While only on day three, the Side Effects are extreme: nausea, can't keep my eyes open, wake up in the middle of the night, anxiety, abd pain, burping, and yes it brings my pain level down, but still need Norco for breakthrough. It feels like a really disagreeable high that I hope goes away with time. Also the pill is, well, I think, heavy and large, hard to swallow, feel like I'm swallowing a small rock. Scared its going to get stuck in my throat. I also had chest pains last night. I've tried every other ER opiate out there, and the only reason I like this one best is it doesn't make me ''high'', the other ones did and that made me want to take more and more hence I dealt with some serious addiction issues, came off all the meds, went thru wdrawl, but when the pain came back I had to succumb. Well I don't want this ''high'' to last! I'm hoping someone out there has more experience with this and can tell me that the side effects will go away because it does cut the pain down.Read More Read Less

I have been taking this for about 3 months. The first month made me a little drowsy but my body has gotten used to it now. I have no side effects but do have some break through pain throughout the day. I am on a very low dose to reduce side effects so I don't notice a difference at all when I take it.

Took one pill an hour before work, Drowsy all day long, and extreme nausea. Pain went from level 9 to level 4 during the day. Wouldn't take it again without something for nausea. I took it with food, and tried to eat again four hours later just to be sure. Sick all day.

The idea of only taking one pill in a 24 hour period is idea, however, for me- I experienced terrible stomach pain & drowsiness. Drowsiness occurring during the day (my working hours -7AM-5PM) & woke up a couple times around 2 or 3 AM not able to sleep. I'd rather manually manage my regular pain meds than to not be able to function efficiently at work due to the drowsiness & definitely due to the stomach pain.

Switching from daily regimen of multiple IR hydrocodone based tablets to a single dose with 42 hour efficacy is very efficient. Each ER tablet dose depending on unknown factors can have analgesic peaks, usually in the evening with sometimes earlier peaking. Overall, the ability to take one tablet per day reduces sense of dependency and assumes a sort of autopilot status regarding pain relief. Initial discomfort regarding the constant 24 hour dosing cycle however the benefits outweigh the self dosing regimen, even if one has a small amount of room in daily regimen to be more acute in targeting pain with "manual" dosing. Read More Read Less