I've just taken my FIRST dose, and like magic...less than 90 minutes and I had the first "near normal" BM I've had in 6 years, since I was paralyzed by a virus that attacked my spine at the T12. Prior to that I had been on pain Meds for 4 years (for disc ruptures in the C Spine, pressing into my spinal chord, and refusal to have neck surgery), but I ALWAYS handled the constipation from Vicodin, then Lorcet, with LOTS OF VEGGIES AND LOTS OF EXERSIZE, distance walking, swimming, and meditation and Yoga, when able. But, after I was unable to walk, and Neuropathic pain was added to the severe neck pain...My need for narcotic pain Meds went up, and I became severely constipated. My only recourse was MORE veggies, daily fiber supplements, stool softeners, Miralax, and Docosol Mini Enemas ! Then all that stopped working, and I had to resort to "manual removal" of mini hard balls, or suffer a complete bowel blockage !! Each month, at my pain clinic, I checked the "severe constipation" box, on the Doctors intake questionnaire !! No help there, it was ignored...until I saw a TV commercial ! Thank God for that...I researched the drug on several Web sites, and asked for a prescription at my appointment 2 days ago. The Doctor had RAVE reviews of the medicine !! But had never bothered to offer it to me. A handicapped patient, who actually has LOWERED MY OPIATE DOSEAGES, and suffered more pain, just to try to have normal bowel movements !! My insurance is good, my co-pay is only $24 !! THANKS TO A COMPANY ADVERTISEMENT I HAVE RELIEF !! I will up date this review, after a few weeks ! But, I have every confidence this will help me. For those with NO or VERY HIGH co-pays, maybe you should contact the drug company, many are very COMPASSIONATE TO YOUR NEEDS, and will help with discounts,coupons etc. GOOD LUCK !!Read More Read Less